Prevalence, Risk Factors and Cutoff Values for Bronchial Hyperresponsiveness to Provocholine in 7-Year-Old Children
Rattachement africain : kr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: A US Food and Drug Administration (FDA)-approved drug methacholine chloride (Provocholine®) was recently introduced to Korea where it is now widely used in clinical practice. We aimed to evaluate the prevalence, risk factors and cutoff value of bronchial hyperresponsiveness (BHR) to Provocholine in 7-year-old children. METHODS: Six hundred and thirty-three children from the Panel Study on Korean Children who visited 16 regional hospitals were evaluated. Skin prick tests, spirometry and bronchial provocation tests for Provocholine as well as a detailed history and physical examinations were performed. The bronchial provocation test was reliably performed on 559 of these children. RESULTS: The prevalence of ever-diagnosed asthma via medical records was 7.7%, and that of current asthma (wheezy episode in the last 12 months + diagnosed asthma by physicians) was 3.2%. The prevalence of BHR to Provocholine was 17.2% and 25.8%, respectively, for a PC20 < 8 and < 16 mg/mL. The risk factors for BHR (PC20 < 16 mg/mL) were atopic dermatitis diagnosis and current dog ownership, whereas those for current asthma were allergy rhinitis diagnosis, a history of bronchiolitis before the age of 3, recent use of analgesics/antipyretics and maternal history of asthma. The BHR prevalence trend showed an increase along with the increased immunoglobulin E (IgE) quartile. The cutoff value of PC20 for the diagnosis of current asthma in children at age 7 was 5.8 mg/mL (sensitivity: 47.1%, specificity: 87.4%). CONCLUSIONS: BHR to Provocholine (PC20 < 8 mg/mL) was observed in 17.2% of 7-year-olds children from the general population and the cutoff value of PC20 for the diagnosis of current asthma was 5.8 mg/mL in this age group. The risk factors for BHR and current asthma showed discrepancies suggesting different underlying mechanisms. Bronchial provocation testing with Provocholine will be a useful clinical tool in the future.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prevalence, Risk Factors and Cutoff Values for Bronchial Hyperresponsiveness to Provocholine in 7-Year-Old Children
- Date Crossref
- 01/01/2018
- Éditeur
- XMLink
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Ulsan College Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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Asan Medical Center pays non établi dans la noticeÉtablissement de santé
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University of Ulsan pays non établi dans la noticeUniversité ou école supérieure
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Seoul National University Hospital Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
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Chonnam National University Hospital Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
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Catholic Kwandong University International St. Mary's Hospital pays non établi dans la noticeÉtablissement de santé
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Catholic Kwandong University Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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Hallym University Sacred Heart Hospital Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
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Seoul National University Bundang Hospital Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
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National Health Insurance Service Ilsan Hospital Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
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National Health Insurance Service pays non établi dans la noticeInstitution
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Gachon University Gil Medical Center Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
Department of Pediatrics — Ulsan College, Asan Medical Center et University of Ulsan, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.