Accès ouvert déclaré 2018 article

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

Jessica van Setten, Jennifer A. Brody, Yalda Jamshidi, Brenton R. Swenson, Anne M. Butler, Harry Campbell, Fabiola Del Greco M, Daniel S. Evans, Quince Gibson, Daníel F. Guðbjartsson, Kathleen F. Kerr, Bouwe P. Krijthe, Leo‐Pekka Lyytikäinen, Christian Müller, Martina Müller‐Nurasyid, Ilja M. Nolte, Sandosh Padmanabhan, Marylyn D. Ritchie, Antonietta Robino, Albert V. Smith, Maristella Steri, Toshiko Tanaka, Alexander Teumer, Stella Trompet, Sheila Ulivi, Niek Verweij, Xiaoyan Yin, Davíð O. Arnar, Folkert W. Asselbergs, Joel S. Bader, John Barnard, Josh Bis, Stefan Blankenberg, Eric Boerwinkle, Yuki Bradford, Brendan M. Buckley, Mina K. Chung, Dana C. Crawford, Marcel den Hoed, Joshua C. Denny, Anna F. Dominiczak, Georg Ehret, Mark Eijgelsheim, Patrick T. Ellinor, Stephan B. Felix, Oscar H. Franco, Lude Franke, Tamara B. Harris, Hilma Hólm, Ilaria Gandin, Mika Kähönen, Ivana Kolčić, Jan A. Kors, Edward G. Lakatta, Lenore J. Launer, Honghuang Lin, Henry J. Lin, Ruth J. F. Loos, Steven A. Lubitz, Peter W. Macfarlane, Jared W. Magnani, Irene Mateo Leach, Thomas Meitinger, Braxton D. Mitchell, Thomas Münzel, George Papanicolaou, Annette Peters, Arne Pfeufer, Peter P. Pramstaller, Olli T. Raitakari, Jerome I. Rotter, Igor Rudan, Nilesh J. Samani, David Schlessinger, Moritz F. Sinner, Jonathan D. Smith, Harold Snieder, Elsayed Z. Soliman, Timothy D. Spector, David J. Stott, Konstantin Strauch, Kirill V. Tarasov, Unnur Þorsteinsdóttir, André G. Uitterlinden, David R. Van Wagoner, Uwe Völker, Henry Völzke, Mélanie Waldenberger, Harm-Jan Westra, Philipp S. Wild, Tanja Zeller, Álvaro Alonso, Christy L. Avery, Stefania Bandinelli, Emelia J. Benjamin, Francesco Cucca, Marcus Dörr, Luigi Ferrucci, Paolo Gasparini, Vilmundur Guðnason, Caroline Hayward, Susan R. Heckbert, Andrew A. Hicks, J. Wouter Jukema, Stefan Kääb, Terho Lehtimäki, Yongmei Liu, Patricia B. Munroe, Afshin Parsa, Ozren Polašek, Bruce M. Psaty, Dan M. Roden, Renate B. Schnabel, Gianfranco Sinagra, Kāri Stefánsson, Bruno H. Stricker, Pim van der Harst, Cornelia M. van Duijn, James F. Wilson, Sina A. Gharib, Paul I. W. de Bakker, Aaron Isaacs, Dan E. Arking, Nona Sotoodehnia

96Citations signalées, ce qui n’est pas une note de qualité

94Institutions déclarées

11Pays d’affiliation déclarés

Rattachement africain : nl, us, gb, it, is, fi, de, ie, se, hr, co. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genome-wide association study of over 92,000 European-descent individuals identifies 44 PR interval loci (34 novel). Examination of these loci reveals known and previously not-yet-reported biological processes involved in cardiac atrial electrical activity. Genes in these loci are over-represented in cardiac disease processes including heart block and atrial fibrillation. Variants in over half of the 44 loci were associated with atrial or blood transcript expression levels, or were in high linkage disequilibrium with missense variants. Six additional loci were identified either by meta-analysis of ~105,000 African and European-descent individuals and/or by pleiotropic analyses combining PR interval with heart rate, QRS interval, and atrial fibrillation. These findings implicate developmental pathways, and identify transcription factors, ion-channel genes, and cell-junction/cell-signaling proteins in atrio-ventricular conduction, identifying potential targets for drug development.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity
Date Crossref: 25/07/2018
Éditeur: Springer Science and Business Media LLC
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Les institutions déclarées

Utrecht University University Medical Center Utrecht University of Washington St George's, University of London Washington State Department of Health Washington University in St. Louis University of Edinburgh Eurac Research Institute for Biomedicine California Pacific Medical Center University of Alabama at Birmingham Hospital deCODE Genetics (Iceland)University of Iceland Erasmus MC Tampere University Tampere University Fimlab (Finland)Universität Hamburg University Medical Center Hamburg-Eppendorf German Centre for Cardiovascular Research University Medical Center Groningen University of Groningen Helmholtz Munich Ludwig-Maximilians-Universität München University of Glasgow University of Pennsylvania IRCCS Materno Infantile Burlo Garofolo University of Michigan Icelandic Heart Association Institute of Genetic and Biomedical Research National Institute on Drug Abuse Universitätsmedizin Greifswald Leiden University Medical Center Boston University Reykjavík University National University Hospital of Iceland Netherlands Heart Institute Farr Institute University College London Johns Hopkins University Cleveland Clinic Lerner College of Medicine The University of Texas Health Science Center at Houston University College Cork Cleveland Clinic Case Western Reserve University Uppsala University Science for Life Laboratory Vanderbilt University Johns Hopkins Medicine Broad Institute Massachusetts General Hospital Texas Cardiac Arrhythmia National Institutes of Health National Institute on Aging University of Trieste Tampere University Hospital University of Split The Lundquist Institute Harbor–UCLA Medical Center Child Health and Development Institute Icahn School of Medicine at Mount Sinai University of Pittsburgh Medical Center TUM Klinikum Technical University of Munich University of Maryland, Baltimore Baltimore VA Medical Center Johannes Gutenberg University Mainz University Medical Center of the Johannes Gutenberg University Mainz National Heart, Lung, and Blood Institute Deutsches Diabetes-Zentrum e.V.German Center for Diabetes Research Heinrich Heine University Düsseldorf Ospedale di Bolzano University of Turku Turku University Hospital University of Leicester NIHR Leicester Biomedical Research Centre Universidad del Rosario Wake Forest University St Thomas' Hospital King's College London Emory University University of North Carolina at Chapel Hill Azienda Sanitaria di Firenze Institute of Genetics and Cancer Medical Research Council Queen Mary University of London Barts Health NHS Trust William Harvey Research Institute Psychiatric Hospital Sveti Ivan Genos (Croatia)Kaiser Permanente Washington Health Research Institute Dutch Health Care Inspectorate Maastricht University

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Cardiac electrophysiology and arrhythmiasGenetic Associations and EpidemiologyCongenital heart defects research

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