Accès ouvert déclaré
2012
article
A framework for human microbiome research
Barbara A. Methé, William Nelson, Mihai Pop, Heather H. Creasy, Michelle Giglio, Curtis Huttenhower, Dirk Gevers, Joseph F. Petrosino, Sahar Abubucker, Jonathan H. Badger, Asif Chinwalla, Ashlee M. Earl, Michael G. FitzGerald, Robert S. Fulton, Kymberlie Hallsworth-Pepin, Elizabeth A. Lobos, Ramana Madupu, Vincent Magrini, John Martin, Makedonka Mitreva, Donna M. Muzny, Erica Sodergren, James Versalovic, Aye Wollam, Kim C. Worley, Jennifer R. Wortman, Sarah Young, Qiandong Zeng, Kjersti M. Aagaard, Olukemi O. Abolude, Emma Allen‐Vercoe, Eric J. Alm, Lucia Alvarado, Gary L. Andersen, Scott Anderson, Elizabeth L. Appelbaum, Harindra Arachchi, Gary C. Armitage, Cesar Arze, Tulin Ayvaz, Carl C. Baker, Lisa Begg, Tsegahiwot Belachew, Veena Bhonagiri, Monika Bihan, Martin J. Blaser, Toby Bloom, Vivien Bonazzi, Paul Brooks, Gregory A. Buck, Christian Buhay, Dana Busam, Joseph L. Campbell, Shane R. Canon, Brandi L. Cantarel, Patrick Chain, I-Min A. Chen, Lei Chen, Shaila Chhibba, Ken Chu, Dawn Ciulla, José C. Clemente, Sandra W. Clifton, Sean Conlan, Jonathan Crabtree, Mary A. Cutting, Noam J. Davidovics, Catherine Davis, Todd Z. DeSantis, Carolyn Deal, Kimberley D. Delehaunty, Floyd E. Dewhirst, Elena Deych, Yan Ding, David J. Dooling, Shannon Dugan, W. Michael Dunne, A. Scott Durkin, R. C. Edgar, Rachel Erlich, Candace N. Farmer, Ruth M. Farrell, Karoline Faust, Michael Feldgarden, Victor Felix, Sheila Fisher, Anthony A. Fodor, Larry J. Forney, Leslie Foster, Valentina Di Francesco, Jonathan Friedman, Dennis C. Friedrich, Catrina C. Fronick, Lucinda Fulton, Hongyu Gao, M. Nathalia Garcia, Georgia Giannoukos, Christina Giblin, Maria Y. Giovanni, Jonathan M. Goldberg, Johannes B. Goll, Antonio González, Allison Griggs, Sharvari Gujja, Brian J. Haas, Holli Hamilton, Emily Harris, Theresa A. Hepburn, Brandi Herter, Diane E. Hoffmann, Michael Holder, Clinton Howarth, Katherine Huang, Susan M. Huse, Jacques Izard, Janet Jansson, Huaiyang Jiang, Catherine Jordan, Vandita Joshi, James A. Katancik, Wendy A. Keitel, Scott T. Kelley, Cristyn Kells, Susan Kinder-Haake, Nicholas B. King, Rob Knight, Dan Knights, Heidi H. Kong, Omry Koren, Sergey Koren, Karthik Kota, Christie Kovar, Nikos C. Kyrpides, Patricio S. La Rosa, Sandra L. Lee, Katherine P. Lemon, Niall J. Lennon, Cecil M. Lewis, Lora Lewis, Ruth E. Ley, Kelvin Li, Konstantinos Liolios, Bo Liu, Yue Liu, Chien‐Chi Lo, Catherine Lozupone, R. Dwayne Lunsford, Tessa Madden, Anup Mahurkar, Peter Mannon, Elaine R. Mardis, Victor Markowitz, Konstantinos Mavrommatis, Jamison McCorrison, Daniel McDonald, Jean E. McEwen, Amy L. McGuire, Pamela McInnes, Teena Mehta, Kathie A. Mihindukulasuriya, Jason Miller, Patrick Minx, Irene Newsham, Chad Nusbaum, Michelle D. O’Laughlin, Joshua Orvis, Ioanna Pagani, Krishna Palaniappan, Shital M. Patel, M.A. Pearson, Jane L. Peterson, Mircea Podar, Craig Pohl, Katherine S. Pollard, Margaret Priest, Lita M. Proctor, Xiang Qin, Jeroen Raes, Jacques Ravel, Jeffrey G. Reid, Mina Rho, Rosamond Rhodes, Kevin Riehle, Maria C. Rivera, Beltran Rodriguez-Mueller, Yu-Hui Rogers, Matthew C. Ross, Carsten Russ, Ravi Sanka, Pamela Sankar, J. Fah Sathirapongsasuti, Jeffery A. Schloss, Patrick D. Schloss, Thomas M. Schmidt, Matthew Scholz, Lynn M. Schriml, Alyxandria M. Schubert, Nicola Segata, Julia A. Segre, William D. Shannon, Richard R. Sharp, Thomas J. Sharpton, Narmada Shenoy, Nihar U. Sheth, Gina Simone, Indresh Singh, Christopher S. Smillie, Jack D. Sobel, Doron D. Sommer, Paul Spicer, Granger G. Sutton, Sean M. Sykes, Diana Tabbaa, Mathangi Thiagarajan, Chad Tomlinson, Manolito Torralba, Todd J. Treangen, Rebecca Truty, Tatiana A. Vishnivetskaya, Jason Walker, Lu Wang, Zhengyuan Wang, Doyle V. Ward, Wesley C. Warren, Mark A. Watson, Kris A. Wetterstrand, James R. White, Katarzyna Wilczek-Boney, Yuan Wu, Kristine M. Wylie, Todd Wylie, Chandri Yandava, Liang Ye, Yuzhen Ye, Shibu Yooseph, Bonnie P. Youmans, Lan Zhang, Yanjiao Zhou, Yiming Zhu, Laurie Zoloth, Jeremy Zucker, Bruce W. Birren, Richard A. Gibbs, Sarah K. Highlander, George M. Weinstock, Richard K. Wilson, Owen White
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Le résumé fourni par la source
A variety of microbial communities and their genes (microbiome) exist throughout the human body, playing fundamental roles in human health and disease. The NIH funded Human Microbiome Project (HMP) Consortium has established a population-scale framework which catalyzed significant development of metagenomic protocols resulting in a broad range of quality-controlled resources and data including standardized methods for creating, processing and interpreting distinct types of high-throughput metagenomic data available to the scientific community. Here we present resources from a population of 242 healthy adults sampled at 15 to 18 body sites up to three times, which to date, have generated 5,177 microbial taxonomic profiles from 16S rRNA genes and over 3.5 Tb of metagenomic sequence. In parallel, approximately 800 human-associated reference genomes have been sequenced. Collectively, these data represent the largest resource to date describing the abundance and variety of the human microbiome, while providing a platform for current and future studies.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
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Les sujets associés
Gut microbiota and healthDiet and metabolism studiesClostridium difficile and Clostridium perfringens research