PO-0757: Non-small cell lung cancer decision support based on distributed learning over multi-center data

Résumé fourni par la source

Purpose or ObjectiveRespiratory motion influences the accuracy of radiation during therapy.In previous study, hypnosis was proposed as a comfortable, effective without side-effects and psychological method to control respiratory motion for lung cancer patients.This study aims to verify the feasibility of hypnosis on respiration control in clinical for chest and abdomen tumor patients during radiotherapy. Material and MethodsAn experiment was carried out in hospital with five patient volunteers of chest or abdomen cancer participating in two conditions of trial, preclinical condition (laboratory peace) and clinical condition (CT machine scanning).The preclinical trial was carried out three days before clinical trial.For every condition, respiratory motion of each volunteer was detected (by BioPac system) for two states, normal state (NS) and hypnotist-guided hypnosis state (HGS).Inter-state and inter-condition difference of respiratory motion were explored. ResultsThe results demonstrated that all volunteers had decreased respiratory amplitude in HGS than NS in preclinical condition (mean amplitude of 11211/6664µV in NS/HGS), while there were only two in clinical condition (mean amplitude of 6278/5907µV in NS/HGS) (Figure 1a).Across all volunteers, it was observed with a mean amplitude deduction of 28.6% in preclinical trail, 5.7% in clinical trial (Figure 1b), indicating the effectiveness of hypnosis for respiratory motion control.Moreover, an overall reduction of coefficient variation in HGS were observed for both preclinical and clinical trial (Figure 1c) which implied that hypnosis is helpful in respiratory stability.End-tail of inspiration/expiration were more close to baseline in HGS than NS for both two conditions, and in clinic than pre-clinic for two states (Figure 1d), indicating less fluctuations in HGS, and in clinical trial.Additionally, in preclinical condition, the motion of duty cycle for phase gating window in HGS was lower than the motion at the corresponding duty cycle in NS (Figure 2a).While no significant difference of duty cycle was observed in clinical condition (Figure 2b).

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