Introduction of a novel magnetic resonance imaging-based scoring system for assessing disease activity in children with juvenile dermatomyositis
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Le résumé fourni par la source
Objectives: We aimed to develop and assess the reliability of a novel MRI-based scoring system for reporting the severity of MRI findings in children with suspected JDM. Methods: Nine consultant paediatric radiologists independently assessed and scored 40 axial and 30 coronal thigh MR images of children with suspected JDM on two occasions using the juvenile dermatomyositis magnetic resonance Imaging Score (JIS). JIS was calculated for both reads for each plane and each limb, with possible scores ranging from 0 (normal) to 100 (severe). Inter- and intraobserver agreement was calculated using the intraclass correlation coefficient (ICC) and two- and one-way random effects models, respectively. Bland-Altman plots of the difference in JIS against the average JIS were also produced for each rater. Results: Overall, the interobserver reliability and agreement was good-for axial images, JIS ranged from 46.8 to 61.0 [ICC = 0.88 (95% CI: 0.82, 0.92)] for the left limb and 47.9-61.4 [ICC = 0.87 (95% CI: 0.81, 0.92)] for the right limb. For coronal images, JIS ranged from 56.7 to 65.1 [ICC = 0.90 (95% CI: 0.85, 0.95)] for the left limb and 55.7 to 66.8 [ICC = 0.90 (95% CI: 0.84, 0.94)] for the right limb. The intraobserver reliability and agreement was good, with ICC ranging from 0.90 to 0.94. Conclusion: JIS is a semi-objective scoring system with potential to serve as a reliable biomarker of disease severity and response to therapeutic interventions in children with JDM.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Introduction of a novel magnetic resonance imaging-based scoring system for assessing disease activity in children with juvenile dermatomyositis
- Date Crossref
- 12/06/2018
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sheffield Teaching Hospitals NHS Foundation Trust Department of Radiology pays non établi dans la noticeOrganisme public
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Sheffield Children's NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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Great Ormond Street Hospital Department of Paediatric Rheumatology pays non établi dans la noticeÉtablissement de santé
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University College London Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
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University of Sheffield pays non établi dans la noticeUniversité ou école supérieure
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Birmingham Children's Hospital Department of Radiology pays non établi dans la noticeÉtablissement de santé
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Leeds Teaching Hospitals NHS Trust Department of Radiology pays non établi dans la noticeÉtablissement de santé
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Alder Hey Children's NHS Foundation Trust Department of Radiology pays non établi dans la noticeÉtablissement de santé
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Royal Manchester Children's Hospital Department of Radiology pays non établi dans la noticeÉtablissement de santé
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Newcastle upon Tyne Hospitals NHS Foundation Trust Department of Radiology pays non établi dans la noticeÉtablissement de santé
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School of Health & Related Research pays non établi dans la noticeUniversité ou école supérieure
Department of Radiology — Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield Children's NHS Foundation Trust et Department of Paediatric Rheumatology — Great Ormond Street Hospital, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.