Accès ouvert déclaré
2018
article
Integrated Molecular Characterization of Testicular Germ Cell Tumors
Hui Shen, Juliann Shih, Daniel P. Hollern, Linghua Wang, Reanne Bowlby, Satish K. Tickoo, Vésteinn Thórsson, Andrew J. Mungall, Yulia Newton, Apurva M. Hegde, Joshua Armenia, Francisco Sánchez-Vega, John Pluta, Louise C. Pyle, Rohit Mehra, Victor E. Reuter, Guilherme Godoy, Jeffrey Jones, Carl Simon Shelley, Darren R. Feldman, Daniel Onofre Vidal, Davor Lessel, Tomislav Kuliš, Flavio Mavignier Cárcano, Kristen Leraas, Tara M. Lichtenberg, Denise Brooks, Andrew D. Cherniack, Juok Cho, David I. Heiman, Michael S. Noble, Xi Liu, Hailei Zhang, Wanding Zhou, Jean C. Zenklusen, Carolyn M. Hutter, Ina Felau, Jiashan Zhang, Nikolaus Schultz, Matthew Meyerson, Xi Liu, David A. Wheeler, Daniel Hughes, Kyle R. Covington, Joy C. Jayaseelan, Viktoriya Korchina, Lora Lewis, Hai Hu, HarshaVardhan Doddapaneni, Donna M. Muzny, Richard A. Gibbs, Katherine A. Hoadley, Benjamin G. Vincent, Shengjie Chai, Christof C. Smith, J. Todd Auman, Yan Shi, Shaowu Meng, Tara Skelly, Donghui Tan, Umadevi Veluvolu, Piotr A. Mieczkowski, Corbin D. Jones, Matthew D. Wilkerson, Saianand Balu, Tom Bodenheimer, Alan P. Hoyle, Lisle E. Mose, Janae V. Simons, Matthew G. Soloway, Jeffrey Roach, Joel S. Parker, D. Neil Hayes, Charles M. Perou, Gordon Saksena, Carrie Cibulskis, Steven E. Schumacher, Rameen Beroukhim, Stacey Gabriel, Adrian Ally, Miruna Balasundaram, Rebecca Carlsen, Dorothy Cheung, Eric Chuah, Noreen Dhalla, Robert A. Holt, Steven J.M. Jones, Yussanne Ma, Michael Mayo, Richard A. Moore, A. Gordon Robertson, Jacqueline E. Schein, Payal Sipahimalani, Angela Tam, Nina Thiessen, Tina Wong, Marco A. Marra, Peter W. Laird, Daniel J. Weisenberger, David Van Den Berg, Phillip H. Lai, Mario Berríos, Andrea Holbrook, Dennis T. Maglinte, Debyani Chakravarty, Jianjiong Gao, Zachary Heins, Ritika Kundra, Angelica Ochoa, Chris Sander, Marc Ladanyi, Amie Radenbaugh, Hailei Zhang, Nils Gehlenborg, Doug Voet, Pei Lin, Scott Frazer, Michael S. Lawrence, Timothy Defreitas, Lynda Chin, Rehan Akbani, John N. Weinstein, Wenbin Liu, Gordon B. Mills, Yiling Lu, Katherine L. Nathanson, Victor E. Reuter, Leendert H. J. Looijenga, Alan H. Bryce, André Lopes Carvalho, Victoria K. Cortessis, Michael Ittmann, Seth P. Lerner, Jay Bowen, Julie M. Gastier‐Foster, Mark Gerken, Carmen Helsel, Nilsa C. Ramirez, Lisa Wise, Erik Zmuda, Sandra Cottingham, David Chesla, Charles Saller, Katherine Tarvin, Luiz Fernando Lopes, Cristovam Scapulatempo‐Neto, Natália D. Aredes, Wolter Oosterhuis, Ad Gillis, Hans Stoop, W M H Eijkenboom, George Sandusky, Sue Martin, Manju Aron, Siamak Daneshmand, Hooman Djaladat, David I. Quinn, Tanya B. Dorff, Jochen K. Lennerz, Leigh B. Thorne, Marija Gamulin, Željko Kaštelan, Tvrtko Hudolin, Christian Kubisch, Lori Boice, Mei Huang, Amy H. Perou, W. Kimryn Rathmell, Todd Pihl, Yunhu Wan, Qiang Sun, Rashi Naresh, Sudha Chudamani, Jia Liu, Laxmi Lolla, Ye Wu, Martin L. Ferguson, Margi Sheth, John A. Demchok, Liming Yang, Roy Tarnuzzer, Heidi J. Sofia, Tanja M. Davidsen
467Citations signalées, ce qui n’est pas une note de qualité
32Institutions déclarées
6Pays d’affiliation déclarés
Rattachement africain : us, ca, br, de, pl, hr.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited high aneuploidy and a paucity of somatic mutations. Somatic mutation of only three genes achieved significance-KIT, KRAS, and NRAS-exclusively in samples with seminoma components. Integrated analyses identified distinct molecular patterns that characterized the major recognized histologic subtypes of TGCT: seminoma, embryonal carcinoma, yolk sac tumor, and teratoma. Striking differences in global DNA methylation and microRNA expression between histology subtypes highlight a likely role of epigenomic processes in determining histologic fates in TGCTs. We also identified a subset of pure seminomas defined by KIT mutations, increased immune infiltration, globally demethylated DNA, and decreased KRAS copy number. We report potential biomarkers for risk stratification, such as miRNA specifically expressed in teratoma, and others with molecular diagnostic potential, such as CpH (CpA/CpC/CpT) methylation identifying embryonal carcinomas.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Integrated Molecular Characterization of Testicular Germ Cell Tumors
- Date Crossref
- 01/06/2018
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Testicular diseases and treatmentsSarcoma Diagnosis and TreatmentRenal and related cancers