The colon and terminal ileum in patients with ankylosing spondylitis and controls in Bangladesh: a macroscopic and microscopic study
Rattachement africain : bd, nl. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Objective.Little is known about gut lesions in AS patients in a developing country, such as Bangladesh.Methods.Full colonoscopy, including the terminal ileum, was performed in 60 AS patients and 20 controls, without diarrhoea, to study macroscopic and microscopic lesions. Results.In the colon, in 60 AS patients 17 macroscopic lesions were found, of which 11 were in the rectum; only one lesion was found in 20 controls.The prevalence of microscopic lesions in the ascending colon, sigmoid colon and rectum was 51, 44 and 50 in patients, respectively, and 13, 9 and 8 in controls.In the terminal ileum, macroscopic and microscopic lesions were seen in 21/56 and 43/56 AS patients, respectively, and in 1/20 and 9/20 controls.In the AS group, macroscopic (38.5 vs 5%, P < 0.01) and microscopic (76.8 vs 45%, P ¼ 0.009) lesions were more frequent than in controls; no IBD was diagnosed.Findings were comparable in the axial AS group (n ¼ 25) and the mainly peripheral group (n ¼ 35).In AS patients, marked eosinophilic infiltration was observed in the ascending colon and sigmoid colon but not in the rectum, and this infiltration was more than in controls.The colonic mucosa in controls was otherwise comparable with western studies.Anaemia was seen in 18/60 cases.No association was found between anaemia or HLA-B27 status and gut lesions. Conclusion.There was an equal percentage of microscopic lesions in the whole gut in AS cases and healthy controls.Previous helminth invasions might have played a role.Lesions differ significantly between AS and controls only in the ileum; therefore, the ileal lesions might be more disease related than the colonic ones.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The colon and terminal ileum in patients with ankylosing spondylitis and controls in Bangladesh: a macroscopic and microscopic study
- Date Crossref
- 01/01/2018
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Bangladesh Medical University pays non établi dans la noticeUniversité ou école supérieure
-
University of Twente pays non établi dans la noticeUniversité ou école supérieure
-
Modern One Stop Arthritis Care and Research Center® (MOAC&RC®) pays non établi dans la noticeStructure de recherche
-
Bangabandhu Sheikh Mujib Medical University (BSMMU) Department of Rheumatology pays non établi dans la noticeUniversité ou école supérieure
-
Department of Gastroenterology pays non établi dans la noticeInstitution
-
Department of Pathology pays non établi dans la noticeInstitution
-
Faculty of Behavioural pays non établi dans la noticeUniversité ou école supérieure
Bangladesh Medical University, University of Twente et Modern One Stop Arthritis Care and Research Center® (MOAC&RC®), avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.