PARAMETERS OF ELASTIC PROPERTIES, ECHOCARDIOGRAPHIC RANGES, INFLAMMATION AND LEVEL OF URIC ACID IN PATIENTS WITH CORONARY HEART DISEASE COMBINED WITH LIVER PATHOLOGY

Le résumé fourni par la source

Objective: To compare the relationship parameters of elastic properties, echocardiographic ranges, inflammation and level of uric acid in patients with coronary heart disease (CHD) combined with liver pathology. Design and method: Studied 59 men (group A) with CHD combined with hepatic steatosis, the group B- 17 patients with CHD without hepatic steatosis. The study group was divided into 3 subgroups according to BMI (subgroup 1 - patients who are overweight, 2 - obesity 1 degree, 3 - obesity grade 2. Evaluated Peterson's elastic modulus (Ep), Young's elastic modulus(Es), echocardiographic ranges, C-reactive protein (CRP), and level of uric acid. Results: Ep and Es in a group A (412,3 ± 142 kPa, 990,6 ± 227 kPa) was lower than in a group B (574,5 ± 158 kPa, 1358 ± 243 kPa p < 0,001). Ep and Ep was lower in the subgroup 1 (370,1 ± 158 kPa, 846 ± 160 kPa) and in subgroup 2 (375 ± 175 kPa, 1041 ± 301 kPa) than in subgroup 3 (522 ± 125 kPa,1106 ± 281 kPa) (p < 0,05). Echocardiographic parameters: diastolic left ventricular (LV) internal dimension, systolic LV internal dimension, LV end-diastolic volume, LV end-systolic volume, LV mass were larger in a group A compared with a group B (5,26 ± 0,37 mm and 4,8 ± 0,1 mm, p = 0,02; 3,47 ± 0,3 mm and 3,08 ± 0,3 mm, p = 0,01; 135,23 ± 23,5 mL and 110,1 ± 6,24 mL, p = 0,03; 50,47 ± 10,85 mL and 38,2 ± 9,2 mL, p = 0,03; 295,1 ± 73,57 g and 184,3 ± 31,6 g p = 0,02). In group A identified the highest levels of uric acid (402 ± 81 mkmol/l) than in the group B (328 ± 12 mkmol/l, p < 0.03). The level of CRP was higher in group A (4,8 ± 1.4 mg/l) than in group B (2,4 ± 1,2 mg/l, p < 0,05). There was correlation between the Ep and LV end-systolic volume (r = 0,93; p < 0,05), ejection fraction (r = −0,89; p < 0,05), carotid plaques (r = 0,67; p < 0,05) in a subgroup 2. The myocardial mass index in a group A associated with level of CRP (r = 0,68; p < 0,05) and level of uric acid (r = 0,56; p < 0,05), however in a group B such connection was not observed. Conclusions: Patients with CHD and liver steatosis showed significant differences in the structural and functional properties of the myocardium with more pronounced disorders of elastic properties of the vascular wall and no correlation with obesity.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.