Common gene variants interactions related to uric acid transport are associated with knee osteoarthritis susceptibility
Rattachement africain : mx, it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: The presence of genetic variants in uric acid (UA) transporters can be associated with hyperuricemia, and therefore with an increased risk of monosodium urate (MSU) crystal precipitation. The inflammatory process triggered by these crystals leads to cartilage damage, which, in turn, could promote knee osteoarthritis (KOA). OBJECTIVE: To determine whether genetic polymorphisms of the UA transporters and their interactions are associated with KOA. MATERIALS AND METHODS: Two hundred forty-three unrelated Mexican-mestizo individuals were recruited for this case-control study. Ninety-three of them were KOA patients but without gout, and one hundred and fifty healthy individuals with no symptoms or signs of KOA were recruited as controls. Forty-one single-nucleotide polymorphisms (SNPs) involved in the UA transporters were genotyped with OpenArray technology in a QuantStudio 12K flex-System with both cases and controls. RESULTS: After adjusting by age, gender, BMI, and ancestry, significant associations were found for eight SNPs: rs1260326 (GCKR), rs780093 (GCKR), rs17050272 (INHBB), rs1471633 (PDZK1), rs12129861 (PDZK1), rs7193778 (IGF1R), rs17786744 (STC1), and rs1106766 (R3HDM2). With respect to gene-gene interactions, the pairwise interactions of rs112129861 (PDZK1) and rs7193778 (IGF1R); rs17050272 (INHBB) and rs1106766 (R3HDM2); rs1106766 (R3HDM2) and rs780093 (GCKR); rs1260326 (GCKR) and rs17786744 (STC1); and rs17786744 (STC1) and rs1106766 (R3HDM2) make it possible to visualize the synergistic or antagonistic effect of their genotypes or alleles on KOA development. CONCLUSIONS: Our preliminary results show that the common gene variants related to UA transport are associated with KOA in the Mexican population. Further studies must be carried out to corroborate it.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Common gene variants interactions related to uric acid transport are associated with knee osteoarthritis susceptibility
- Date Crossref
- 11/07/2018
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Instituto Nacional de Rehabilitación pays non établi dans la noticeStructure de recherche
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University of Padua pays non établi dans la noticeUniversité ou école supérieure
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Instituto Politécnico Nacional Escuela Superior de Medicina pays non établi dans la noticeUniversité ou école supérieure
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Synovial Fluid Laboratory Musculoskeletal and Rheumatic Diseases Division pays non établi dans la noticeStructure de recherche
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University of Padova Department of Medicine - DIMED pays non établi dans la noticeUniversité ou école supérieure
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National Institute of Respiratory Diseases Center for Research in Infectious Diseases pays non établi dans la noticeStructure de recherche
Instituto Nacional de Rehabilitación, University of Padua et Escuela Superior de Medicina — Instituto Politécnico Nacional, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.