Nadciśnienie płucne u pacjentów z przewlekłą chorobą nerek

Le résumé fourni par la source

Recent studies have shown that the incidence of pulmonary hypertension (PH) increases from the earliest stages of chronic kidney disease (CKD). From the 3 rd stage of CKD, prevalence of PH significantly exceeds the values found in the general population and in the group of hemodialysis patients (HD), PH is related to 30–60% of patients. In addition, HD patients as well as pre-dialysis patients have a significant proportion of patients with pre-capillary PH. The incidence of arterial PH in dialysis patients is several hundred times higher than in the general population. Occurrence of PH is associated with increased mortality and worse kidney transplant results. The pathogenesis of PH in this population is multifactorial and not fully understood (V group of clinical classification). The most important factors associated with the development of PH include: uremic vasculopathy, contractile and diastolic dysfunction of the myocardium, valvular defects, presence of arteriovenous fistulas, conduction, calcification of vessels, contact with dialysis membranes, endothelial dysfunction of the blood vessels and chronic inflammation. The following article discusses epidemiology, pathogenesis, clinical consequences and PH diagnostic and therapeutic procedures in the CKD patients group, and above all in patients undergoing renal replacement therapy with dialysis.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.