Accès ouvert déclaré
2018
article
Overweight is associated to a better prognosis in metastatic colorectal cancer: A pooled analysis of FFCD trials
Thomas Aparicio, Michel Ducreux, Roger Faroux, Emilie Barbier, Sylvain Manfrédi, Thierry Lecomte, Pierre-Luc Etienne, Laurent Bedenne, Jaafar Bennouna, Jean–Marc Phelip, E. François, Pierre Michel, Jean-Louis Legoux, Mohamed Gasmi, Gilles Breysacher, Philippe Rougier, Aimery de Gramont, Côme Lepage, Olivier Bouché, Jean‐François Seitz, A. Adenis, Adam Alessio, Amar Aouakli, A. Azzedine, Ahmed Bedjaoui, Anne Thirot Bidault, A Blanchi, A. Botton, A. Cadier-Lagnes, Abdelaziz Fatisse, A. Gagnaire, Alexandra Gilbert, A. Gueye, Antoine Hollebecque, A Lemaire, Abakar Mahamat, A B Marre, Arnaud Patenotte, Alexander Rotenberg, Arnaud Roussel, Anne Thirot‐Bidault, A. Votte, A. Weber, A. Zaanan, Anne-Claire Dupont-Gossart, Anne-Laure Villing, A M Queuniet, B. Coudert, Bernard Denis, Beatriz García, B Lafforgue, B. Landi, Bernard Leduc, B. Linot, B Paillot, B. Rhein, B. Winkfield, Claude Barberis, Catherine Becht, C. Belletier, Christine Berger, C. Bineau, C. Borel, Catherine Brézault, C Buffet, Corina Cornila, Caroline Couffon, Christelle de la Fouchardière, C. Giraud, C. Lécaille, Céline Lepère, Camille Lobry, C. Locher, Catherine Lombard‐Bohas, Claude Paoletti, Christian Platini, Christine Rebischung, Corinne Sarda, Catheline Vilain, C. Briac-Levaché, D. Auby, D. Baudet-Klepping, Dominique Béchade, Dominique Besson, D Cléau, D Festin, D. Gargot, Dominique Genet, D Goldfain, Dominique Luet, David Malka, Denis Péré-Vergé, D. Pillon, D. Sevin-Robiche, D. Smith, D. Soubrane, David Tougeron, D Zylberait, Élisabeth Carola, Emmanuel Cuillerier, E. Dorval Danquechin, E Echinard, Ellen Janssen, E. Maillard, Emmanuel Mitry, E. Norguet-Monnereau, Etienne Suc, E. Terrebonne, E Zrihen, E A Pariente, Françoise Almaric, Franck Audemar, Franck Bonnetain, Françoise Desseigne, F. Dewaele, F. Di Fiore, François Ghiringhelli, F. Husseini, Faïza Khemissa, F. Kikolski, F. Morvan, F Petit-Laurent, François Riot, Fabien Subtil, F. Zerouala-Boussaha, François‐Xavier Caroli‐Bosc, G. Boilleau-Jolimoy, Gilbert Bordes, G. Cavaglione, G. Coulanjon, G. Deplanque, G. Gatineau-Saillant, Gaël Goujon, G. Medinger, Guillaume Roquin, Hedia Brixi‐Benmansour, H. Castanie, H Lacroix, H Maechel, Hervé Perrier, Hassan Al Salloum, Hélène Senellart, Isabelle Baumgaertner, Isabelle Cumin, Ivan Graber, I. Trouilloud, Julian Boutin, J. Butel, J Charneau, J Crétin, Jérôme Dauba, J. Deguiral, Joëlle Egreteau, J. Ezenfis, J. Forestier, Jacques Goineau, J Lacourt, J Lafon, Juan José Borrero Martín, Jérôme Meunier, Johanna Moreau, J. Provençal, Julien Taı̈eb, J. Thaury, J Tuaillon, J. Vergniol, J Villand, Jean‐Louis Vincent, Julien Volet, Jean‐Baptiste Bachet, Jean‐Claude Barbare, J. C. Souquet, J D Grange, J.F. Dor, J.F. Paitel, Jean-Luc Jouve, Jean‐Luc Raoul, J.M. Cheula, J.M. Gornet, Jean‐Marc Sabaté, J Vantelon, Jean-Nicolas Vaillant, J.P. Aucouturier, J. Barbieux, Jacob Herr, J.P. Lafargue, J.-P. Lagasse, J.P. Latrive, J.-P. Plachot, Julie Ramain, Jean-Paul Robin, J.P. Spano, J.-Y. Douillard, K. Beerblock, Karine Bouhier‐Leporrier, Kara Slimane Fawzi, L. Cany, Laurence Choné, Laëtitia Dahan, Laurent Gasnault, Lukáš Rob, Laëtitia Stefani, Lionel Wander, Mathieu Baconnier, Méher Ben Abdelghani, M. Benchalal, M. Blasquez, M. Carreiro, Marina Charbit, M. Combe, Muriel Duluc, M. Fayolle, M Gignoux, Marc Giovannini, M Glikmanas, May Mabro, M. Mignot, M. Mornet, M Mousseau, M. Mozer, Matthias Pauwels, M Pelletier, M. Porneuf, Mohamed Ramdani, Matthieu Schnee, M. Tissot, Mohamed-Ayman Zawadi, Marie-Christine Clavero-Fabri, M.C. Gouttebel, M.C. Kaminsky, Marie‐Pierre Galais, Naceur Abdelli, Nicolas M. Barrière, N. Bouaria, Nadia Bouarioua, Nicolas Delas, N. Gérardin, N. Hess-Laurens, Noël Stremsdoerfer, Olivier Berthelet, Olivier Boulat, Olivier Capitain, Olivier Favre, P Amoyal, P. Bergerault, Pascal Burtin, P Cassan, P Chatrenet, Pascale Chiappa, Pierre Claudé, Patrice Couzigou, P Feydy, Philippe Follana, Pierre A. Geoffroy, P Godeau, Pascal Hammel, P. Laplaige, P Lehair, Petra Martin, P. Novello, P. Pantioni, P. Pienkowski, Philippe Pouderoux, Patricia Prost, P. Ruszniewski, P Souillac, Patrick Texereau, P Thévenet, P.A. Haineaux, R. Benoit, Romain Coriat, R. Lamy, R Mackiewicz, Sylvain Béorchia, Stanislas Chaussade, Sandrine Hiret, Stéphane Jacquot, S. Lavau Denes, Sarah Montembault, Stéphane Nahon, S Nasca, Si Van Nguyen, S. Oddou-Lagranière, S. Pesque-Penaud, Serge Fratté, Thierry Chatellier, Touraj Mansourbakht, T Morin, Thomas Walter, Valérie Boige, V. Bourgeois, V. Derias, Véronique Guerin‐Meyer, Vincent Hautefeuille, V. Jestin Le Tallec, Véronique Lorgis, V. Quentin, Virginie Sebbagh, Véronique Veuillez, Xavier Adhoute, X. Coulaud, Y. Bécouarn, Yvan Coscas, Y Courouble, Yann Le Bricquir, Yann Molin, Yves Rinaldi, You Heng Lam, Z. Ladhib
46Citations signalées, ce qui n’est pas une note de qualité
28Institutions déclarées
1Pays d’affiliation déclarés
Rattachement africain : fr.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Previous studies showed that high and low body mass index (BMI) was associated with worse prognosis in early-stage colorectal cancer (CRC), and low BMI was associated with worse prognosis in metastatic CRC (mCRC). We aimed to assess efficacy outcomes according to BMI. PATIENTS AND METHODS: A pooled analysis of individual data from 2085 patients enrolled in eight FFCD first-line mCRC trials from 1991 to 2013 was performed. Comparisons were made according to the BMI cut-off: Obese (BMI ≥30), overweight patients (BMI ≥ 25), normal BMI patients (BMI: 18.5-24) and thin patients (BMI <18.5). Interaction tests were performed between BMI effect and sex, age and the addition of antiangiogenics to chemotherapy. RESULTS: The rate of BMI ≥25 patients was 41.5%, ranging from 37.6% (1991-1999 period) to 41.5% (2000-2006 period) and 44.8% (2007-2013 period). Comparison of overweight patients versus normal BMI range patients revealed a significant improvement of median overall survival (OS) (18.5 versus 16.3 months, HR = 0.88 [0.80-0.98] p = 0.02) and objective response rate (ORR) (42% versus 36% OR = 1.23 [1.01-1.50] p = 0.04) but a comparable median progression-free survival (PFS) (7.8 versus 7.2 months, HR = 0.96 [0.87-1.05] p = 0.35). Subgroup analyses revealed that overweight was significantly associated with better OS in men. OS and PFS were significantly shorter in thin patients. CONCLUSION: Overweight patients had a prolonged OS compared with normal weight patients with mCRC. The association of overweight with better OS was only observed in men. The pejorative prognosis of BMI <18.5 was confirmed.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Overweight is associated to a better prognosis in metastatic colorectal cancer: A pooled analysis of FFCD trials
- Date Crossref
- 01/07/2018
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Cancer Risks and FactorsColorectal Cancer Screening and DetectionNutrition and Health in Aging