SP094EFFECT OF SHORT TERM CPAP TREATMENT ON BLOOD PRESSURE IN PATIENTS WITH HYPERTENSION AND MODERATE-TO-SEVERE OSA

Le résumé fourni par la source

INTRODUCTION AND AIMS: Continuous positive airway pressure (CPAP) is a well-known and well-accepted treatment of obstructive sleep apnoea (OSA). Previous studies of CPAP treatment in OSA patients have shown conflicting results on the effect on blood pressure (BP) levels, and these studies have not included patients with impaired renal function. METHODS: Seventeen patients with hypertension and mean eGFR 66 mL/min/1,73 m2 with a total range [29;99] were diagnosed with moderate-to-severe OSA (AHI≥15) in a preceding study in the Renal Outpatients Clinic, Holstebro Hospital. At baseline and after a median of 89 days of CPAP treatment, patients were examined with office BP, 24h ambulatory BP monitoring (ABPM), blood samples (creatinine), 24h urine sampling (u-albumin), cardio respiratory monitoring (Apnoea Hypopnea Index, AHI), and Epworth Sleepiness Scale (ESS, reporting of sleep symptoms). RESULTS: At follow-up, significant decrease in office systolic BP (SBP) (149±13 vs. 136±15 mmHg, p<0.05), 24h SBP (143±11 vs. 136±8 mmHg, p<0.05), and daytime SBP (146±11 vs. 138±9 mmHg, p<0.05) was seen. Night time BP did not change significantly (131±16 vs. 125±14 mmHg, p=0.23). AHI decreased and mean oxygen saturation increased, both significantly (33 vs. 2, p<0.0001 and 92 vs. 95%, p=0.001, respectively). ESS (5 vs. 4, p=0.112) and mean eGFR (p=0.77) did not change. Mean 24h urinary excretion of albumin decreased (11 vs. 8.5 mg/24h, p<0.05). CONCLUSIONS: CPAP treatment in this hypertensive population with mean eGFR 66 mL/min/1,73 m2 demonstrated a significant effect on BP and urinary albumin excretion. No effects on renal function or sleep symptoms were seen. Reduced AHI and increased nocturnal oxygen saturation demonstrated that patients responded to CPAP treatment. Consequently, these results show that decrease in BP is obtainable in this population in addition to lowered level of albuminuria.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.