P488Circulating markers of vascular wall lesion in asymptomatic atherosclerosis

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Background: As systemic inflammation may play an important role in the pathogenesis of atherosclerosis (AS) and coronary heart disease (CHD) there is interest in the relevance of circulating markers of vascular wall lesion and inflammation to asymptomatic AS (AAS) in comparison to CHD. Purpose: of our investigation was to assess the diagnostic and prognostic value of numerous biomarkers reflecting immune inflammation in prediction of clinical manifestation of CHD. Methods: 120 persons with determined AAS were observed during 3 years. Baseline levels of pro-inflammatory cytokines (IL1β, IL6, TNF-α) and antibodies against connective tissue components (collagen –antiС-ab, hyaluronic acid – antiHA-ab, chondroitin sulfate antiCS-ab) were evaluated by ELISA. Control group included 117 pts with acute (47 pts) or chronic (70 pts) CHD, and 52 pts with AH without clinical and instrumental data consistent with AS. In controls the same markers were investigated. In AAS group cardiovascular events (CVE) including CV death, acute coronary syndrome and stroke were analyzed. On the basis of statistical methods including regression and ROC-analysis we determined the most informative predictors of CVE in AAS group.

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