Effect of Spinosad and Imidacloprid on Serum Biochemical Alterations in Male Broilers and Its Amelioration with Vitamin E and Silymarin

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The present experiment was conducted on 120 male broiler chicks which were divided into six groups of 20 each. Group 1 served as control, group 2 treated with imidacloprid @ 50 ppm in feed, group 3 was treated with spinosad @ 1000 ppm in feed, group 4 was treated with imidacloprid @ 50 ppm and spinosad @ 1000 ppm in feed, group 5 was treated with imidacloprid @ 50 ppm, spinosad @ 1000 ppm and Vitamin E @ 20 ppm in feed and group 6 was treated with imidacloprid @ 50 ppm, spinosad @ 1000 ppm and silymarin @ 1000 ppm in feed. The experiment was carried out for 4 weeks. The blood samples were collected for separation of serum to analyze various biochemical parameters on 14 and 28 days after oral administration the compounds mentioned above. The biochemical assays showed a significant (P < 0.05) increase in serum ALP, significant (P < 0.05) decrease in serum total protein, insignificant decrease in serum AChE and an insignificant increase in serum ACP in all groups when compared to control. Group 5 and 6 showed numerically decreased values of serum ALT and increase in TP when compared to group 4. Liver tissue biochemical profile revealed a significant (P < 0.05) reduction in GSH concentration in liver of group 2, 3 and 4 and a mild to moderate improvement was noticed in group 5 and 6 when compared to group 4. These results revealed that exposure of Imidacloprid, spinosad and its combination resulted in alterations in serum and tissue biochemical parameters.

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