Neopterin, kynurenine and tryptophan as new biomarkers for early detection of rectal anastomotic leakage.
Rattachement africain : cz, rs. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
INTRODUCTION: At present, there are no strong predictors, nor a useful scoring system, that clearly identifies patients at risk for anastomotic leakage. AIM: This study aimed to investigate a new method that assesses this risk by monitoring levels of neopterin, tryptophan, and kynurenine, in bodily fluids. MATERIAL AND METHODS: This prospective study included patients who underwent elective rectal resection for carcinoma. The basic condition for inclusion was rectal anastomosis using the double-stapling technique. Preoperative levels of neopterin, tryptophan, kynurenine, and their ratios, were assessed with blood and urine samples. These levels were then monitored for 6 postoperative days in venous blood, urine, and abdominal drainage fluid. RESULTS: A total of 42 patients were enrolled in the study. Thirty-six patients underwent a laparoscopic resection and 6 patients had an open procedure. No differences were found among neopterin, tryptophan, and kynurenine serum levels. However, the groups were observed to have significant differences in the urinary neopterin/creatinine ratio: the preoperative neopterin/creatinine ratio was 139.5 μmol/mol in the group with leakage, vs 114.8 μmol/mol in the group without complications, p = 0.037. The same results were observed during the postoperative period, p = 0.012. Additionally, the group with complications had a higher mean value of neopterin in drainage fluid, p = 0.048. CONCLUSIONS: Our study demonstrated that high preoperative levels of urinary neopterin could be interpreted as a risk for anastomotic leakage. Moreover, pathological levels of neopterin in urine and abdominal drainage fluid could be useful for early identification of anastomotic leakage during the postoperative period prior to its clinical development.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Neopterin, kynurenine and tryptophan as new biomarkers for early detection of rectal anastomotic leakage.
- Date Crossref
- 07/02/2018
- Éditeur
- "Medycyna Praktyczna" Spolka Jawna
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Charles University pays non établi dans la noticeUniversité ou école supérieure
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University Hospital Hradec Králové Department of Surgery pays non établi dans la noticeOrganisme public
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University of Defence pays non établi dans la noticeUniversité ou école supérieure
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University of Hradec Králové pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Military Health Sciences in Hradec Kralove Department of Military Surgery pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Pharmacy in Hradec Kralove Department of Analytical Chemistry pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Informatics and Management Department of Informatics and Quantitative Methods pays non établi dans la noticeUniversité ou école supérieure
Charles University, Department of Surgery — University Hospital Hradec Králové et University of Defence, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.