The Effects of Isolated Fractions of Mesobuthus eupeus Scorpion Venom on Humoral Immune Response.
Rattachement africain : ir. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: scorpion venom fractions as an immunomodulator. METHODS: The venom fractions collected from Khuzestan Province in South West of Iran were purified by ion exchange chromatography. Elution of the bounded elements was done by using a linear gradient of sodium chloride (0.1, 0.25, 0.5, 0.75, 1, 1.25, 1.5 and 2 molar). The fractions were analyzed by Bradford spectrophotometric and SDS-PAGE method. After treatments of chicken with venom fractions and sheep red blood cell (SRBC), direct haemagglutination test in microtiter plate was used for the determination of the chicken SRBC antibody titer. RESULTS: The fraction released by NaCl 1.25M had the highest protein concentration. The highest and lowest antibody titer was determined at the fifth (NaCl 0.75 molar) and seventh fraction (NaCl 1.25 molar), respectively. CONCLUSION: faction's venom treatment. It is due to biological functions of venom components. Purification of these elements would provide the new agents for immune responses manipulation.
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Où se fait cette recherche
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Shahid Chamran University of Ahvaz pays non établi dans la noticeUniversité ou école supérieure
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Razi Vaccine and Serum Research Institute pays non établi dans la noticeEntreprise
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Faculty of Veterinary Medicine Department of Pathobiology pays non établi dans la noticeUniversité ou école supérieure
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Razi Reference Laboratory of Scorpion Research pays non établi dans la noticeStructure de recherche
Shahid Chamran University of Ahvaz, Razi Vaccine and Serum Research Institute et Department of Pathobiology — Faculty of Veterinary Medicine, avec 1 autre affiliation.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.