Synthetic analysis of associations between IL-10 polymorphisms and skin cancer risk

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// Hongbo Zhao 1 , Jiaoli Yang 1 , Zhenzhen Yu 1 , Hui Shen 1 , Xinlin Huang 1 , Mi Zhang 1 , Teng Long 1 , Cailing A 1 and Wenhui Wang 2 1 Department of Dermatology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China 2 Department of Traditional Chinese Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China Correspondence to: Wenhui Wang, email: whwang_shiyan@126.com Keywords: IL-10; skin cancer; polymorphism; meta-analysis Received: September 04, 2017 Accepted: December 04, 2017 Published: December 17, 2017 ABSTRACT The current study was designed to quantitatively summarize the evidence for the strength of the associations between common IL-10 functional polymorphisms and skin cancer risk. Relevant publications concerning the associations between common IL-10 functional polymorphisms(–1082G>A, –819C>T and –592C>A) and skin cancer were retrieved by a comprehensive electronic literature search in PubMed, Web of Science, EBSCO, Embase, China National Knowledge Infrastructure, Wan­fang, Chinese Biomedical Database (CBM). The odds ratio (OR) and 95% confidence interval (CI) were utilized to assess the strength of the relationship. A total of 26 studies including 4090 cases and 4133 controls (–1082G>A, 10 studies with 1809 cases and 1830 controls; –819C>T, 7 studies with 862 cases and 957 controls; –592C>A, 9 studies with 1419 cases and 1346 controls) were enrolled in the meta-analysis. Overall, the results revealed a borderline decreased risk of skin cancer in heterozygote model (OR = 0.82, 95CI = 0.67–1.00, p = 0.05). The subgroup analysis also presented similar association for non-melanoma skin cancer in heterozygote model (OR = 0.67, 95CI = 0.50–0.91, p = 0.01). Moreover, the further analysis based on the histological type of non-melanoma skin cancer indicated a significantly decreased risk of BCC in allele model (OR = 0.67, 95% CI = 0.50–0.91, p = 0.02) and dominant model (OR = 0.68, 95% CI = 0.48–0.98, p = 0.04). However, neither overall analysis nor subgroup analysis based on cancer subtype revealed a significant association of –1082G>A or –592C>A polymorphisms with skin cancer. The present study suggested a potential association between IL-10 –819C>T polymorphism and decreased risk of skin cancer, but a lack of association for –1082G>A and –592C>A polymorphisms. Further invalidation is urgently needed.

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