Graft Function and Incidence of Biliary Stenosis After Use of UW or IGL1 Preservation Solutions for Liver Transplantation.

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PURPOSE: To comparatively evaluate the outcome of liver grafts and recipient patients after perfusion of IGL1 or UW preservation solutions to liver transplantation. METHODS: Randomized prospective study evaluated 43 hepatic transplants by means of the following data: clinical and laboratory profile of donors, postoperative hepatic enzymes levels and post-transplant complications. RESULTS: UW was used in 21 cases whereas 22 were perfused with IGL1 preservation solution. Norepinephrine dose, length of ICU stay, cause of brain death and Donor Risk Index were similar for IGL1 and UW groups. Recipients presented with similar gender distribution, age and MELD scores. Recipient's AST, ALT, LDH, and total bilirubin levels had similar values from the first to seventh postoperative day (p > 0.05). Allograft dysfunction, primary non-function of the graft, and death rates were similar between groups. Biliary stenosis were four times more prevalent in UW perfused group (19%) as compared to IGL1 (4.5%), p > 0.05. This complication was significantly higher in the UW perfused graft when a subgroup of donors younger than 60 years of age was considered (p = 0.048). CONCLUSION: Perfusion of liver grafts with IGL1 solution resulted in similar outcome when compared to UW perfused graft. A trend to lower biliary complications was observed and a significantly lower rate of biliary damage was confirmed in transplants of grafts younger than 60 years old.

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