Antioxidant Activity of gossypitrin isolated from the petals of Talipariti elatum (Sw.) Fryxell (Malvaceae) in Cuba

Résumé fourni par la source

Talipariti elatum Sw.Fryxell (Malvaceae) is an endemic tree widely distributed in Cuba.The flowers are used in traditional medicine for the treatment of asthma.It was decided to search for any product responsible of this devoted activity.From the flower leaves (petals) it was isolated a flavonoid glycoside characterized as Gossypitrin and a sample was evaluated for its in vitro scavenging effects on reactive oxygen species (ROS) (O .-,HO ., HOCl, ROO ., and H 2 O 2 ), reactive nitrogen species (RNS) (ONOO -and NO) and ABTS •+ , DPPH .radicals and Reducing Power assay.Additionally, two enzymatic assays (Inhibition of xanthine oxidase (XO) and Effect on XO activity) were also evaluated.In the scavenging assays the sample showed to be not effective against all assayed ROS and RNS, and displayed a weak activity in the DPPH and Reducing Power assays, but it displayed a good activity in the ABTS •+ assay (2, 14 mM).The enzymatic assays corroborated that Gossypitrin shows a weak activity on inhibition of XO.These results provide scientific support for the empirical use of the flowers of T. elatum as an antasthmatic medicine.

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