Non-office-hours admission affects intravenous thrombolysis treatment times and clinical outcome
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Le résumé fourni par la source
In patients treated with intravenous thrombolysis (IVT), an unfavourable ‘non-office-hours effect’ on door-to-needle time (DNT) and clinical outcome has been suggested. This effect has been attributed to a number of factors, mostly related to either less efficient logistics or less (experienced) staffing during non-office hours (NH). These factors could result in longer DNTs and more protocol violations and thus in worse clinical outcome. On the other hand, one could also argue that the workload during NH is lower, which could result in less time delays in the various diagnostic processes and thus in better clinical outcome. Our hypothesis is that admission during NH has a negative effect on onset-to-needle time (ONT), DNT and clinical outcome in IVT patients. The ThRombolysis in Ischaemic Stroke Patients (TRISP) study is a collaboration of 12 European stroke centres and comprises a cohort of over 10 000 consecutive patients treated with IVT.1 We used data of patients treated up to 31 December 2014 (see online supplementary appendix file 1). We excluded patients receiving additional mechanical thrombectomy, those with symptom onset during hospital stay and those who woke up with stroke symptoms. Office hours (OH) and national or regional holidays were collected for each participating centre. Patients were categorised as admitted during NH if their door time was outside OH or during holidays. Outcome and safety measures were ONT, DNT, symptomatic intracerebral haemorrhage (according to European Cooperative Acute Stroke Study II criteria), 3-month mortality and 3-month functional outcome assessed with the modified Rankin Scale . ### Supplementary file 1 [SP1.pdf] Baseline characteristics and treatment times were compared between patients admitted during NH and OH using χ2 tests, Student’s t-tests and Mann-Whitney U tests, where appropriate. In the multivariate ONT and …
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Non-office-hours admission affects intravenous thrombolysis treatment times and clinical outcome
- Date Crossref
- 25/10/2017
- Éditeur
- BMJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Amsterdam UMC Location University of Amsterdam pays non établi dans la noticeÉtablissement de santé
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University of Helsinki Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
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University Hospital of Basel Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Inserm pays non établi dans la noticeOrganisme public
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Université de Lille pays non établi dans la noticeUniversité ou école supérieure
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Berlin Institute of Health at Charité - Universitätsmedizin Berlin pays non établi dans la noticeStructure de recherche
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Center for Stroke Research Berlin Department of Neurology pays non établi dans la noticeStructure de recherche
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Heidelberg University pays non établi dans la noticeUniversité ou école supérieure
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University Hospital Heidelberg Department of Neurology pays non établi dans la noticeÉtablissement de santé
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University Hospital of Bern pays non établi dans la noticeÉtablissement de santé
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University of Brescia Department of Clinical and Experimental Sciences pays non établi dans la noticeUniversité ou école supérieure
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Azienda Unita' Sanitaria Locale Di Modena pays non établi dans la noticeOrganisme public
Amsterdam UMC Location University of Amsterdam, Department of Neurology — University of Helsinki et Department of Neurology — University Hospital of Basel, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.