P3428Prospective controlled trial testing the effect of physical training over myocardial perfusion disturbance and quality of life in patients with primary microvascular angina: a pilot study

Résumé fourni par la source

Background: Primary microvascular angina (PMA) is a common condition associated with quality of life (QoL) and physical capacity (PC) deterioration, allied to frequent angina recurrence. PMA is recognized as a condition in which pharmacological interventions yield poor results in the control of ischemia and angina symptoms. Purpose: We aimed at evaluating the impact of physical training (PT) over the PC, QoL, and the extent of reversible myocardial perfusion defects (rMPD) in patients with PMA. Methods: We prospectively investigated 32 patients with PMA, characterized by effort angina, normal coronary arteries at coronary angiography and ≥2 myocardial segments with rMPD at stress-rest Sestamibi-Tc99m myocardial perfusion SPECT (MPS). At baseline, patients underwent SF-36 QoL questionary, cardiopulmonary exercise test and MPS. After that, they were assigned to a PT-group (n=23, 56±9 years old, 11 males) and a Control-group (n=9, 53±7 years old, 8 males), which was constituted by patients that declined the invitation to participate in the PT program. The PT-patients were submitted to 1-hour aerobic exercise in treadmill, 3 times/week, moderate intensity (60–85% of peak-VO2), during 3-months. All patients in both groups were re-evaluated after 3-months, with the same methods used at baseline.

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