P3620The extrinsic and intrinsic pathways of coagulation are considerably activated in patients with paroxysmal atrial fibrillation

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Background: Clinical interest in the haemostasis profile of patients with paroxysmal atrial fibrillation (PAF), and in particular, in blood coagulation is significant. It is known that blood coagulation is activated in two pathways: extrinsic and intrinsic. The extrinsic pathway is initiated by the tissue factor (TF), which forms a complex with factor VII (F VII) and activates it. The intrinsic pathway is triggered by the contact of factor XII (F XII) with the subendothelial space and its subsequent activation. Regardless of the activation method, the coagulation cascade ends with a final common pathway, in which the activated factor X (FX) is central to the prothrombin complex, responsible for the conversion of prothrombin (factor II (F II)) to thrombin that converts fibrinogen into fibrin. Purpose: To study the coagulation system in patients with clinical manifestation of PAF<24 hours. Materials and methods: 51 non-anticoagulated patients (26 men, 25 women; mean age 59.84±1.60 years) and 52 controls (26 men, 26 women; mean age 59.50±1.46 years) corresponding in age, gender, comorbidities and conducted treatment, were consequently selected for the study. TF levels and coagulation activity of F II, F VII, F X and F XII were examined in plasma. Enzyme-linked immunoassays and kinetic enzyme tests were used.

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