Effect of Oral Clonidine onPost Operative Nausea andVomiting in GynecologicalLaparoscopic Surgery

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Introduction & Objective: Despite advances in anesthesia nausea and vomiting is still a frequent post operative complication of general anesthesia for laparoscopic surgery. Many treatment modalities have been tried to reduce this unpleasant side effect. In this study we assessed the efficacy of oral clonidine in laparoscopic surgery in gynecological laparoscopic surgery. Materials & Methods: In this prospective double blind study, 86 ASA classes 1 or 2 were selected. Study group (n=43) received clonidine (0.2 mg tablet with 50 cc water) 60 – 90 minutes before surgery while control group ( n=43) received placebo. The patients were monitored for presence of nausea and vomiting for 24 hours. Moreover sedation scores and hemodynamic changes between 2 groups were compared. Collected data were analyzed by SPSS using chi–square and Fisher tests. Results: Nine patients (20.9%) in study group and 19 patients (44.2%) in control group nauseated (p = 0.0 21) while 16.3% of patients in study group and 34.9% in control group vomited (p = 0.048). Conclusion: Clonidine had statistically significant effect on reducing the incidence of both nausea and vomiting. It is a simple effective solution and its routine use can be suggested in gynecological laparoscopic surgery.

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