Heterocyclic chalcone derivatives: Synthesis and biological activity evaluation
Rattachement africain : pt. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Aim: Synthesis of new heterocyclic chalcone derivatives with promising antitumor activity. Introduction: Natural chalcones have been intensively studied for their wide range of biological activities, namely antitumor.1 Possessing two electrophilic reactive centers at α,β-unsaturated ketone group, chalcone derivatives can participate in addition reactions leading to the synthesis of promising bioactive compounds with a more rigid structure, like isoxazoles and pyrazoles.2 Methods: Chalcones were synthesized by base catalysed Claisen Schmidt condensation via microwave assisted organic synthesis (MAOS). The antiproliferative activity was assessed using sulforhodamine B assay.3 Results: Seventeen chalcone derivatives were synthesized and identified as having in vitro growth inhibitory activity on three human tumor cell lines from breast, lung and melanoma (MCF-7, NCI-H460, and A375-C5). Conclusion: Most of the synthetized chalcones revealed to be promising growth inhibitors of human tumor cell lines. The molecular mechanisms involved in their antiproliferative effect are being evaluated. Acknowledgements: This research was partially supported through national funds provided by FCT, ERDF and COMPETE under the Strategic Funding UID/Multi/04423/2013, and the projects PTDC/MAR-BIO/4694/2014 (POCI-01-0145-FEDER-016790), PTDC/DTPFTO/1981/2014 (POCl-01-0145-FEDER-016581), and PTDC/AAGTEC/0739/2014 (POCI-01-0145-FEDER-016793) in the framework of the programme PT2020 as well as by the project INNOVMAR-Innovation and Sustainability in the Management and Exploitation of Marine Resources (NORTE-01-0145-FEDER-000035, within Research Line NOVELMAR), supported by NORTE 2020, under the PORTUGAL 2020 Partnership Agreement, through the ERDF. Patrícia M.A. Silva is a PhD fellowship holder from FCT (SFRH/BD/90744/2012).
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Heterocyclic chalcone derivatives: Synthesis and biological activity evaluation
- Date Crossref
- 01/09/2017
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Universidade do Porto Faculdade de Farmácia pays non établi dans la noticeUniversité ou école supérieure
-
University of Coimbra pays non établi dans la noticeUniversité ou école supérieure
-
Cooperativa de Ensino Superior Politécnico e Universitário pays non établi dans la noticeUniversité ou école supérieure
-
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde CESPU pays non établi dans la noticeStructure de recherche
-
University of Algarve CBMR pays non établi dans la noticeUniversité ou école supérieure
-
Universidade de Coimbra Faculdade de Farmácia pays non établi dans la noticeUniversité ou école supérieure
Faculdade de Farmácia — Universidade do Porto, University of Coimbra et Cooperativa de Ensino Superior Politécnico e Universitário, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.