SLE - Update Ethiopathogenesis Leading to Biological Therapy

Le résumé fourni par la source

Systemic lupus erythematosus is a chronic, autoimmune disorder which may have even fatal consequences, particularly if it affects vital organs of the human body. It is typically manifested by inflammation of various organ systems. The course of the disease includes sporadic flare-ups, or relapses, which may lead to irreversible damage of the organs. The focus is on the suppression of clinical symptoms, inhibition of the formation of autoantibodies induce remission, preventing relapse and irreversible organ damage while maintaining the best possible quality of life for the patient. The traditional treatment of SLE include corticosteroids, cyclophosphamide and cyclosporine A, in severe forms are widely used in addition to azathioprine and high doses of immunoglobulins. In recent years, intensive research into the pathogenesis of SLE appeared other potential targets for therapeutic intervention.

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