Hepatitis C virus control: viral resistance, new therapeutic targets and host defense
Le résumé fourni par la source
Hepatitis C virus (HCV) has chronically infected infects more than 170 million humans, making it a mojor health threat. First directly acting antivirals were protease inhibitors (Boceprevir and Telaprevir) associated with drug resistance. We studied viral resistance to protease inhibitors, crystallised the HCV non-structural 5b protein as a new target for anti-HCV drug development, and studied the role of several host defence proteins in HCV infection.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.