CLINICO-BACTERIOLOGICAL PROFILE OF URINARY TRACT INFECTIONS IN CHILDREN AND RESISTANCE PATTERN OF UROPATHOGENS- A STUDY FROM SOUTH INDIA

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BACKGROUND \nUrinary tract infection is a common problem in children. Early diagnosis and prompt treatment is very important for preventing \nits complications like renal parenchymal disease. Emergence of multidrug-resistant bacteria has made treatment of urinary tract \ninfection a challenge in children. \nThe aim of the study is to determine the clinico-bacteriological profile of urinary tract infections in children and resistance \npattern of uropathogens. \nMATERIALS AND METHODS \nA cross-sectional study was conducted in children ≤12 years with suspected urinary tract infections from October 2011 to \nFebruary 2012 in a tertiary care centre. Urine samples were collected for urinalysis and culture. Antibiotic susceptibility test was \nperformed as per the Clinical and Laboratory Standards Institute (CLSI) guidelines. \nRESULTS \nOut of 550 children studied significant bacteriuria detected in 90 (16.4%) cases. Males constituted 60% and females 40%. \nInfants (31.2%), 1-5 years (35.5%) and 5-12 years (33.3%) were the age distribution. Fever was present in 93.4% and specific \nurinary symptoms in 48.9% children. Blood culture was positive in 4.8%. E. coli (57.8%), Klebsiella spp. (22.3%), Proteus \n(6.7%), Pseudomonas spp. (6.7%), Enterobacter (4.4%) and methicillin-resistant staphylococcus aureus (2.2%) were the \nuropathogens. Multidrug-resistant isolates were 65.6%. Sensitivity and specificity of pyuria was 71.2% and 76.6%, respectively. \nCONCLUSION \nUrinary tract infection should be ruled out in all febrile children with no obvious focus of infection. MDR uropathogens should \nbe considered while initiating treatment in children with UTI.

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