Birth Weight and Preterm Delivery Outcomes of Perinatally vs Nonperinatally Human Immunodeficiency Virus-Infected Pregnant Women in the United States: Results From the PHACS SMARTT Study and IMPAACT P1025 Protocol
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BACKGROUND: Pregnancy outcomes of perinatally human immunodeficiency virus-infected women (PHIV) are poorly defined. METHODS: We compared preterm delivery and birth weight (BW) outcomes (low BW [LBW], <2500 g), small-for-gestational-age [SGA], and BW z scores [BWZ]) in HIV-exposed uninfected infants of PHIV vs nonperinatally HIV-infected (NPHIV) pregnant women in the Pediatric HIV/AIDS Cohort Study Surveillance Monitoring of ART Toxicities or International Maternal Pediatric Adolescent AIDS Clinical Trials P1025 studies. Mixed effects models and log binomial models were used to assess the association of maternal PHIV status with infant outcomes. Age-stratified analyses were performed. RESULTS: From 1998 to 2013, 2270 HIV-infected pregnant women delivered 2692 newborns (270 born to PHIV and 2422 to NPHIV women). PHIV women were younger, (mean age 21 vs 25 years, P < .01) and more likely to have a pregnancy CD4 count <200 cells/mm3 (19% vs 11%, P = .01). No associations between maternal PHIV status and preterm delivery, SGA, or LBW were observed. After adjustment, BWZ was 0.12 lower in infants of PHIV vs NPHIV women (adjusted mean, -0.45 vs -0.33; P = .04). Among women aged 23-30 years (n = 1770), maternal PHIV was associated with LBW (aRR = 1.74; 95% confidence interval, 1.18, 2.58; P < .01). CONCLUSION: The overall lack of association between maternal PHIV status and preterm delivery or infant BW outcomes is reassuring. The higher rates of LBW observed in PHIV women aged 23-30 years warrants further mechanism-based investigations as this is a rapidly growing and aging population worldwide. CLINICAL TRIALS REGISTRATION: PHACS SMARTT study, NCT01310023. CLINICAL TRIALS REGISTRATION: IMPAACT 1025, NCT00028145.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Birth Weight and Preterm Delivery Outcomes of Perinatally vs Nonperinatally Human Immunodeficiency Virus-Infected Pregnant Women in the United States: Results From the PHACS SMARTT Study and IMPAACT P1025 Protocol
- Date Crossref
- 30/05/2017
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Icahn School of Medicine at Mount Sinai Departments of Medicine and Obstetrics pays non établi dans la noticeUniversité ou école supérieure
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Cancer Research And Biostatistics pays non établi dans la noticeOrganisation à but non lucratif
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University of Southern California Saban Research Institute of Children’s Hospital Los Angeles pays non établi dans la noticeUniversité ou école supérieure
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Children's Hospital of Los Angeles pays non établi dans la noticeOrganisme public
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Saban Research Institute pays non établi dans la noticeStructure de recherche
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Duke Medical Center pays non établi dans la noticeÉtablissement de santé
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The State University of New Jersey Rutgers pays non établi dans la noticeUniversité ou école supérieure
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Rutgers New Jersey Medical School pays non établi dans la noticeUniversité ou école supérieure
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Boston Children's Hospital Division of Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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Harvard University pays non établi dans la noticeUniversité ou école supérieure
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Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal and Pediatric Infectious Disease Branch pays non établi dans la noticeStructure de recherche
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University of Miami Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
Departments of Medicine and Obstetrics — Icahn School of Medicine at Mount Sinai, Cancer Research And Biostatistics et Saban Research Institute of Children’s Hospital Los Angeles — University of Southern California, avec 9 autres affiliations.
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