Effets prophylactiques de l’huile essentielle de Syzygium aromaticum chez les rats wistar en développement coexposés au plomb et au manganèse

Le résumé fourni par la source

The objective of this study is, on the one hand, to evaluate the changes in the oxidative state at the brain level induced by co-exposure to lead (0.2%) and manganese (4.79 g/l) in young wistar rats during the gestation and lactation period, and on the other hand, to test the effectiveness of clove essential oil Syzygium aromaticum (HEC) in relieving the harmful effects of these two metals studied by an intraperitoneal injection of 0.1 ml HEC/kg/day over a period of 21 days. The characterization of this essential oil by gas chromatography coupled with mass spectrometry indicates that the major components are: eugenol (80.83%), acetate eugenyl (10.48%), and β-caryophyllene (7.21%). Chronic co-exposure led to disturbance in antioxidant enzymatic activities (superoxide dismutase, glutathione peroxidase, and catalase) in intoxicated rats compared to control rats. Indeed, the histological study of the cerebral cortex and cerebellum showed very marked lesions translated by degeneration of the nerve cells and activation of the microglia. Moreover, HEC administration restored the activity of the various antioxidant enzymes with a marked improvement in brain tissue architecture in intoxicated rats treated with HEC.

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