Prevalence and determinants of chronic kidney disease in northeast of Iran: Results of the Golestan cohort study
Rattachement africain : ir, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: The burden of chronic kidney disease (CKD) is increasing globally in particular in fast emerging economies such as Iran. Population-based studies on prevalence of CKD in Iran are scarce. The objective of the current study was to explore the prevalence and determinants of CKD in the setting of Golestan Cohort Study (GCS), the largest prospective cohort in the Middle East. METHODS: In this observational study, 11,409 participants enrolled in the second phase of GCS were included. Sex, age, literacy, residence, anthropometric measurements, smoking, opium use, self-reported history of cardiovascular diseases (heart disease and/or stroke), hypertension, diabetes, and lipid profile were the predictors of interest. The outcomes of interest were eGFR and CKD defined as eGFR< 60 ml/min/1.73m2. RESULTS: Mean (SD) of GFR was 70.0 ± 14.7 ml/min/1.73m2 among all participants, 68.2 ± 14.2 among women, and 72.0 ± 15.0 among men. Prevalence of CKD was 23.7% (26.6% in women, 20.6% in men). The prevalence of CKD stages 3a, 3b, 4, and 5 were 20.0%, 3.3%, 0.4% and 0.1%, respectively. Female sex, older age, urban residence, history of CVD, hypertension or diabetes, larger body mass and surrogates of body fat and opium use were all associated with CKD. Opium had a significant positive association with CKD in adjusted model. All anthropometric measurements had positive linear association with CKD. Being literate had inverse association. Sex had significant interaction with anthropometric indices, with higher odds ratios among men compared with women. A significantly high association was observed between the rate of change in waist circumference and systolic blood pressure with risk of CKD. CONCLUSION: One in four people in this cohort had low eGFR. Obesity and overweight, diabetes, hypertension, and dyslipidemia are major risk factors for CKD. Halting the increase in waist circumference and blood pressure may be as important as reducing the current levels.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prevalence and determinants of chronic kidney disease in northeast of Iran: Results of the Golestan cohort study
- Date Crossref
- 03/05/2017
- Éditeur
- Public Library of Science (PLoS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Shiraz University of Medical Sciences Non-Communicable Diseases Research Center pays non établi dans la noticeUniversité ou école supérieure
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Tehran University of Medical Sciences Digestive Diseases Research Center pays non établi dans la noticeUniversité ou école supérieure
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Shariati Hospital pays non établi dans la noticeÉtablissement de santé
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Morgan State University pays non établi dans la noticeUniversité ou école supérieure
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Golestan University Golestan Research Center of Gastroenterology and Hepatology pays non établi dans la noticeUniversité ou école supérieure
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Golestan University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Iranian Academy of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of California pays non établi dans la noticeUniversité ou école supérieure
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UCLA Health pays non établi dans la noticeÉtablissement de santé
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VA Long Beach Healthcare System pays non établi dans la noticeÉtablissement de santé
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School of Community Health and Policy Department of Public Health Analysis pays non établi dans la noticeUniversité ou école supérieure
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UCLA Fielding School of Public Health Department of Epidemiology pays non établi dans la noticeUniversité ou école supérieure
Non-Communicable Diseases Research Center — Shiraz University of Medical Sciences, Digestive Diseases Research Center — Tehran University of Medical Sciences et Shariati Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.