Resuscitation of Pseudomonas aeruginosa from dormancy requires hibernation promoting factor (PA4463) for ribosome preservation

Le résumé fourni par la source

Significance The dormant subpopulations of Pseudomonas aeruginosa biofilms are linked to chronic infections because dormant cells tolerate antibiotic treatment and then repopulate the infections when conditions become favorable. Dormant cells must maintain cellular integrity, including preformed ribosomes, to resuscitate. The small-ribosome–binding proteins, ribosome modulation factor, and hibernation promoting factor (HPF) have evolved to maintain ribosomes in an inactive state. Using both population and single-cell–level studies, we show that HPF provides the primary mechanism used by P. aeruginosa to maintain ribosome integrity during dormancy, and that HPF is required for optimal P. aeruginosa resuscitation from dormancy. Preventing regrowth of the dormant subpopulation by targeting HPF may provide an effective means for eliminating the dormant subpopulations of P. aeruginosa infections.

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