SP254CLINICAL EVALUATION OF RENAL TUBULO-INTERSTITIAL NEPHROPATHY BY ASSESSING RENAL BLOOD FLOW WITH ULTRASONOGRAPHY

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Introduction and Aims: In Japan, the incidence of ischemic tubulo-interstitial nephropathy (TIN) associated with renal vascular disorder is thought to increase with aging. However, adequate tools for the clinical assessment of TIN are not available. Here we evaluated the clinical utility of renal vascular Doppler ultrasonography (RV-US) for the assessment of TIN, and we investigated the correlation between a variety of parameters obtained using RV-US and the urine N-acetylglusaminidase-to-creatinine ratio (NAG index), a conventional clinical parameter for TIN evaluations. Methods: Patients who were suspected of having renovascular disorder (RV group, n=51) and patients with biopsy-proven glomerulonephritis excluding diabetes (GN group, n=20) as a control were enrolled and analyzed in a retrospective crossover design. We focused on and evaluated the peak systolic velocity (PSV) and resistive index (RI) measured at two different points independently, with the main trunk of the renal artery (RA) and intra-renal branch of the renal artery corresponding to the inter-lobular artery (LA).

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.