Morphology, Aggregation Properties, Cytocompatibility, and Anti-Inflammatory Potential of Citrate-Stabilized AuNPs Prepared by Modular Ultrasonic Spray Pyrolysis
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Le résumé fourni par la source
Ultrasonic Spray Pyrolysis (USP) possesses a great potential for production of higher quantities of gold nanoparticles (AuNPs), thus overcoming the problem of batch-to-batch variations in their properties. Recently, we demonstrated that USP with an additional evaporation chamber (modular USP) led to a better size control of AuNPs. However, their morphology, stability, toxicity, and immunomodulatory properties have not been investigated completely. Here, two types of spherical AuNPs were produced by using different USP parameters, followed by their stabilization in Na-citrate solution. No significant changes in their size, agglomeration, and z -potential occurred 3 months after their initial production in citrate solution. However, the conditioning of AuNPs in serum-containing cell culture media for 24 h induced an increase in the AuNPs’ hydrodynamic size and a red shift in their Surface Plasmon Resonance, pointing to their instability in biological media. Cytocompatibility tests showed that the produced AuNPs were internalized by L929 cells and primary human monocytes and were not cytotoxic at the concentrations lower than 200 μg/mL, but they exhibited antiproliferative and anti-inflammatory effects, respectively. AuNPs reduced the percentage of CD14+CD16+but not CD14lowCD16+monocytes in vitro and reduced the expression of CD86, HLA-DR, TNF-α, and IL-12/IL-23 by these cells. These results indicate that the anti-inflammatory effects of citrate-capped AuNPs produced by modular USP could be beneficial for their application in the treatment of inflammatory conditions.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Morphology, Aggregation Properties, Cytocompatibility, and Anti-Inflammatory Potential of Citrate-Stabilized AuNPs Prepared by Modular Ultrasonic Spray Pyrolysis
- Date Crossref
- 01/01/2017
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Maribor Institute of Materials Technology pays non établi dans la noticeUniversité ou école supérieure
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Zlatarna Celje (Slovenia) pays non établi dans la noticeEntreprise
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University of Belgrade Institute for the Application of Nuclear Energy pays non établi dans la noticeUniversité ou école supérieure
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Indian Institute of Technology Dhanbad pays non établi dans la noticeUniversité ou école supérieure
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University of Ljubljana pays non établi dans la noticeUniversité ou école supérieure
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National Institute of Chemistry pays non établi dans la noticeStructure de recherche
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RWTH Aachen University IME Institute pays non établi dans la noticeUniversité ou école supérieure
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Military Medical Academy Institute for Medical Research pays non établi dans la noticeÉtablissement de santé
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Zlatarna Celje d.d. pays non établi dans la noticeInstitution
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Indian Institute of Technology (ISM) pays non établi dans la noticeStructure de recherche
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Faculty of Chemistry and Chemical Technology pays non établi dans la noticeUniversité ou école supérieure
Institute of Materials Technology — University of Maribor, Zlatarna Celje (Slovenia) et Institute for the Application of Nuclear Energy — University of Belgrade, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.