Young Investigator Award session: Basic Science311Intraventricular flow patterns after percutaneous mitral valve repair with MitraClip implantation312Papillary muscles contribute significantly to shortening of dilated left ventricles313Relationship between cardiac uptake by 99mTc-DPD scintigraphy and left ventricular longitudinal strain in patients with transthyretin-related cardiac amyloidosis314Premature ventricular contraction in resynchronized patients with short atrio-ventricular delay: hemodynamic impact beyond A-wave truncation

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early ejection flow (axis-flow angle, or AFA).Results: 25 patients (67% male, aged 72 611.7,LVEF 39.2610.8)were included in the study.KED and AFA were measured in all patients in optimal AVD (Opt) and short AVD (Opt -60 ms).Student's t test showed a significant difference in KED between short (48,76 6 8,33 J/m*s) and optimal AVD (24,32 6 8,61 J/m*s, p<0,0001) in early ejection.The Flow -LV-Axis Angle was significantly narrower in short AVD vs. optimal AVD (20,2 6 1,9 vs. 10,1 6 1,3 , p<0.01), which implied that flow collided with the mitral valve and mitro-aortic junction before being ejected, with consequent energy dissipation, in short but not in optimal AVD.See Figure 1.Conclusions: Premature ventricular contraction due to short atrio-ventricular delay impacts LV flow dynamics causing higher kinetic energy dissipation due to impaired flow redirection to the LV outflow tract, which adds to the compromise of LV filling due to A wave truncation in explaining poor response to CRT in patients with suboptimal AVD programming.

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