HIT Moderated Poster session: imaging in everyday practiceP143Relationship of FDG-PET and pressure-strain loops as novel measures of regional myocardial workload in LBBB-like dyssynchronyP144Cardiotoxicity of anti-vascular endothelial growth factor therapies: results of a pilot studyP145A new animal model of rapid pacing-induced dilated cardiomyopathy and LBBBP146Three-dimensional echocardiography assessment of the systolic variation of effective regurgitant orifice area in patients with functional tricuspid regurgitation: implications for quantificationP147Clinical prognostic value of myocardial mechanics using speckle-tracking echocardiography in patients post primary coronary intervention for acute ST- segment elevation myocardial infarctionP148Relationship between left atrial volumes and emptying fractions and parameters of infarct size and left ventricular filling pressures in survivors of st elevation myocardial infarctionP149Left atrial dysfunction assessed by two dimensional sp

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Purpose: To investigate the relationship between two measures of regional myocardial workload (RMW): regional myocardial glucose metabolism, assessed by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and regional LV pressure-strain loop area.Both were evaluated in a chronic rapid pacing animal model of dilated cardiomyopathy (DCM) and LBBB-like mechanical dyssynchrony.Methods: Nine sheep were subjected to rapid RV pacing (180 bpm), developing LV dilatation and asymetric remodelling, with LBBB-like ventricular activation.After 8 weeks all animals underwent two FDG-PET scans: one under normal LV conduction (AAI pacing), another under LBBB-like activation (DDD pacing).Potential inhomogeneities in RMW represented by FDG-uptake, were then evaluated.Before the last PET scan, all animals were subjected to invasive pressure-volume and simultaneous echocardiographic circumferential strain (CS) analysis of the mid-ventricular segments.Segmental pressure-CS-loop area was then recorded as alternative measure of RMW and compared to PET results.Results: DDD and AAI pacing led to different, but reproducible patterns of inhomogeneous RMW distribution (Figure ) with a significant decreased septal-to-lateral wall ratio of RMW in DDD mode compared to AAI, both in the FDG-uptake (0.87 + 0.09 vs 1.05 + 0.15, resp., p=0.005) and pressure-strain loops area (0.22 + 0.18 vs 0.94 + 0.23, resp., p=0.0001).A significant correlation was found between both measures (r=0.584,p=0.018).Conclusions: Our study indicates that RMW can be measured with both regional FDG-uptake and the area of regional pressure-strain loops.The influence of motion and partial volume on the reconstructed FDG-uptake in the asymmetrically remodelled hearts is currently being investigated.

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