2015 article

Natural history of asymptomatic gallstones: differential behaviour in male and female subjects.

S Sood, Than Winn, Suraiya Ibrahim, Anisha Gobindram, Asha Arumugam, Norain Che Razali, Putri Adara Yasmin, Norul Hidayu, H Komaili Sani, Mohd Habib Mustafa, Anis Fatinah, Athifah Abdul Karim, Kadhim Jawad Obaid, Nor Hashim Haron, Henry Fitjerald, Marymol Koshy

13Citations signalées, ce qui n’est pas une note de qualité

9Institutions déclarées

1Pays d’affiliation déclarés

Rattachement africain : my. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

OBJECTIVE: The natural history of asymptomatic (silent) gallstones has been inadequately studied. Existing information derives from studies based on oral cholecystography or relatively small sample sizes. We planned a retrospective cohort study in subjects with gallstones to determine conversion rates from asymptomatic to symptomatic. METHODS: We extracted data from computerised databases of one government hospital and two private clinics in Malaysia. Files were scrutinised to ensure that criteria for asymptomatic gallstones were fulfilled. Patients were called on telephone, further questioned to confirm that the gallstones at detection were truly asymptomatic, and asked about symptoms that were consistent with previously defined criteria for biliary colic. Appropriate ethical clearances were taken. RESULTS: 213 (112 males) patients fulfilled the criteria for asymptomatic gallstones and could be contacted. 23 (10.8%) developed pain after an average follow up interval of 4.02 years (range 0.1-11 years). Conversion rates from asymptomatic to symptomatic gallstones were high in the first two years of follow up, averaging 4.03±0.965 per year. Over time the conversion rates slowed, and by year 10 the annual conversion rate averaged only 1.38±0.29. Conversion rates were much higher for females compared to males (F:M hazard ratio 3.23, SE 1.54, p>z 0.014). The lifetime risks for conversion approached 6.15% for males, and 22.1% for females. CONCLUSION: In conclusion, asymptomatic gallstones are much more likely to convert to symptomatic in females than in males. Males in whom asymptomatic stones are discovered should be advised conservative treatment. Surgery may be preferable to conservative management if the subject is a young female.

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Monash University Malaysia pays non établi dans la notice
Université ou école supérieure
Newcastle University Medicine Malaysia pays non établi dans la notice
Université ou école supérieure
Mahsa University pays non établi dans la notice
Université ou école supérieure
Department of Statistics Malaysia pays non établi dans la notice
Organisme public
IMU University pays non établi dans la notice
Université ou école supérieure
University Kebangsaan Malaysia Medical Centre pays non établi dans la notice
Établissement de santé
Universiti Teknologi MARA pays non établi dans la notice
Université ou école supérieure
National Defence University of Malaysia pays non établi dans la notice
Université ou école supérieure
Hospital Selayang pays non établi dans la notice
Établissement de santé
Hospital Putrajaya pays non établi dans la notice
Établissement de santé
Mahameru International Medical Centre pays non établi dans la notice
Institution
Twin Tower Medical Center pays non établi dans la notice
Établissement de santé

Monash University Malaysia, Newcastle University Medicine Malaysia et Mahsa University, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Gallbladder and Bile Duct DisordersKidney Stones and Urolithiasis TreatmentsCholangiocarcinoma and Gallbladder Cancer Studies

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