Monitoring of fluconazole in serum of patients undergoing hemodiafiltration by solid-phase extraction and high-performance liquid chromatography with ultraviolet detection.
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
A high-performance liquid chromatographic assay for monitoring the antifungal drug fluconazole in human serum was developed using a C18 reversed-phase column with isocratic elution. The method involved sample clean-up by solid-phase column extraction, and subsequent analysis required only 14 min per sample for separation and quantitation. The assay was precise, with intra- and inter-assay relative standard deviations of < or = 1.5% and < or = 3.1%. The minimum detectable concentration of fluconazole was 0.3 nmol/ml. This assay has the advantage of minimizing the risk of interference from co-administered drugs to critically ill patients undergoing hemodiafiltration.
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Showa Pharmaceutical University Department of Analytical Chemistry of Medicines pays non établi dans la noticeUniversité ou école supérieure
Department of Analytical Chemistry of Medicines — Showa Pharmaceutical University.
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