Prognostička vrijednost imunohistokemijske ekspresije 8-okso-7,8-dihidro-2'-deoksigvanozina u bolesnika s kolorektalnim karcinomom [Prognostic value of 8-oxo-7,8dihydro-2'-deoxyguanosine immunohistochemical expression in patients with colorectal cancer ]

Le résumé fourni par la source

Abstract: Role of the oxidative stress in the carcinogenesis of colorectal cancer is still \nunclear. 8-oxo-7,8-dihydro-2´-deoxyguanosine (8-oxodG) is a marker of \ndeoxyribonucleic acid (DNA) damage and a potential marker for carcinogenesis. The \nhypothesis of this study is that increased expression of 8-oxo-7,8-dihydro-2´- \ndeoxyguanosine in colorectal cancer is associated with higher tumor stage and \nshorter overall survival. The aim of this study was to identify 8-oxodG by \nimmunohistochemistry in tumor tissue and surrounding normal mucosa in patients \nwith colorectal cancer and to find out if its expression correlates with survival, \ndepending on the stage of the disease according to the IUCC classification. The \nstudy was conducted on samples of patients operated for colorectal cancer at the \nDepartment of Surgery, University Hospital Center Zagreb, between January 1999 \nand December 2000. A total of 146 patients were identified and 8 were excluded due \nto lack of clinical data on disease progress. The final results were thus obtained by \nanalyzing data of 138 patients. The study proved the relationship between the \npresence of 8-oxodG and worse survival in patients who underwent colorectal \ncancer surgery. Higher percentage of 8-oxodG positive tumors cells correlated with \nadvanced disease stage. A positive correlation of the intensity of 8-oxodG reaction \nwith advanced disease stage was not found. This can be explained by the relatively \nsmall number of patients, especially after dividing the cohort along various stages of \nthe IUCC classification. Larger prospective studies are therefore needed to explain \nthe effect of oxidative stress on the process of carcinogenesis in patients with \ncolorectal cancer.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.