Accès ouvert déclaré
2013
article
Heterogeneity in tumour content and necrosis in primary lung cancers: Implications for molecular analysis
Felicia Goh, Edwina Duhig, Belinda E. Clarke, Andrew Dettrick, David Godbolt, Kayla Tran, Louise Franz, Jeremy Barr, Kylie Parsonson, Maria do Rosário Oliveira Martins, M. Davidson, Casey M. Wright, John De laat, Janet G. Shaw, Jennifer Martin, Brielle Parris, Eloise Shaw, Laura De Souza, Jane Tjahjadi, Marissa Daniels, Jill E. Larsen, Annalese Semmler, Rachel Stockwell, Santiyagu M. Savarimuthu, Vandana Relan, Krishna Bajee Sriram, Jennifer Campbell, Samuel Kim, Maxine E. Tan, Leanne Morrison, Kelly Chee, Emily Impey, Annalicia Vaughan, Sasha A. Rahman, Nick Chang, Morgan Windsor, Rishendran Naidoo, Kevin Matar, Robert Tam, P. Cole, I Yang, Rayleen Bowman, Kwun Fong
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Résumé fourni par la source
Lung adenocarcinoma (AC) and squamous cell carcinoma (SCC) tumours have a large variance in tumour cell content. This heterogeneity is a concern for genomic studies, as it is difficult to distinguish mutational differences between tumour and non-tumour if low percentage tumour is used for analysis. In addition to this, tumour samples are affected by the amount of necrosis present, as the overall number of viable cells is decreased. We assessed tumour and necrotic content in lung tumour specimens from AC and SCC patients and aimed to identify possible implications for the suitability of these samples in molecular characterisation studies using next generation sequencing technology.
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Sujets associés
Lung Cancer Treatments and MutationsCancer Genomics and DiagnosticsRNA modifications and cancer