280 Prospective international observational registry of patient at risk for atherothrombotic events: the French data

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Introduction: The S3-NIV questionnaire was recently developed to provide clinicians with a simple and reliable tool to assess important domains such as respiratory symptoms, sleep quality and NIV-related side-effects in patients treated with home NIV. Methods: The S3-NIV questionnaire was administered at hospital admission and hospital discharge in consecutive patients admitted for an acute episode of respiratory failure to test its responsiveness to changes in health status. Results: 19 patients (8 males, median age 64yrs (interquartile range [IQR]: 55-76) were enrolled at admission. Median length of stay was 14 days (IQR: 7-22). Mean S3-NIV questionnaire score at admission was 4.83 (SD 1.59, 95% CI 4.07 to 5.60) and 6.08 (SD 1.77, 95% CI 5.22 to 6.94) at discharge with a mean difference of 1.24 (SD 1.09, 95% CI 0.71 to 1.77, p<0.001). Conclusion: Our observation suggests that the S3-NIV questionnaire is responsive to recovery from severe episode of respiratory failure. Further studies to estimate MCID of the S3-NIV questionnaire are ongoing.

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