Study on exposure level in environment media,human body loading and toxic effects of Di(2-ethylhexy1) phthalate

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Objective To explore the exposure level in environment media,the concentration of DEHP in plastic containers was studied by gas chromatography.Methods The concentration of MEHP(the main breakdown chemical of DEHP) in students' urine was measured by high performance liquid chromatography.ResultsFurthermore,the toxic effect of DEHP in liver,kidney cells of rat was also observed.The exposure concentration of DEHP was 0,5,20 and 80 μmol.L-1.Conclusions After 1-hour exposure,the content of malondialdehyde(MDA) and the coefficient of DNA-protein crosslink(DPC) were examined.Results showed both MDA content and DPC coefficient in liver and kidney cells increased gradually with the increase of DEHP concentration It was suggested that DEHP could induce acute oxidative damage in liver and kidney cells of rat.

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