Analysis for the prognosis of young women with lung adenocarcinoma

Résumé fourni par la source

Objective To explore the survival and prognosis of young women with lung adenocarcinoma.Methods 282 surgi- cally treated patients with lung adenocareinoma were analyzed retrospectively.Kaplan-Meier and Cox regression were used to analyze the relationship between the prognostic factors and survival time.Results Kaplan-Meier analysis showed that at 5 years the survival were 20.0%for smokers and 36.4%for non-smokers(P=0.021).The 5-year survival rates for staging Ⅰ,Ⅱ,Ⅲ,Ⅳ were 65.7 % (Ⅰa66.1%,Ⅰb60.5%),30.9%(Ⅱa36.3%,Ⅱb27.5%),11.4%(Ⅲa 12.3%,Ⅲb6.8%)and3.6%,respectively (P0.001).The survival rates of the number of involved lymph nodes3 and≤3 were 19.1%and 38.3%,respectively(P= 0.006),and the survival rates of different differentiation were 65.2%,29.5%and 19.8%,respectively(P0.001).Multivariate analysis indicated that smoking,p-TNM and differentiation were independent prognostic factor,the relative risk(RR)was 3.315, 2.809 and 1.195,respectively.Conclusion Smoking,p-TNM,the number of involved lymph nodes and differentiation were corre- lated with the survival.Smoking、p-TNM and differentiation are independent prognostic factor for the survival of young women with lung adenocarcinoma,comprehensive smoking control efforts and total lymphadenectomy are important to the survival of lung adenocar- cinoma among young women.

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