Clinical distribution and drug-resistance of staphylococcus aureus isolated from female genital tract in 2008-2013

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Objective To investigate the distribution and the change of drug resistance of staphylococcus aureus(SAU)isolated from female genital tract, and provide evidence for rational use of antibiotic. Methods Non-repetitive staphylococcus aureus isolates were collected from female genital tract from January 2008 to December 2013. The identification and susceptibility of the isolates were determined using auto-microbe analyzer. The data were analyzed by WHONET 5.6. Results A total of 247 SAU stains were determined, mainly from the outpatient(69.2%), mean age(26.3±4.2) years old. The rate of Methicillin-resistant Staphylococcus aureus(MRSA) isolates rose from 13.5% in2008 to 31.9% in 2013, and showed an increasing trend year by year. The results of antibiotic susceptibility test displayed that the resistance rates of SAU to penicillin and erythromycin were higher than 58.7%, and the resistance rates to others antibiotic were low(25.9%). No isolate was resistant to linezolid and vancomycin. Resistance rates to oxacillin,levofloxacin, tetracycline had a significant increasing trend from 2008 to 2013(P0.05). MRSA strains to oxacillin,ampicillin/sulbactam, gentamicin, levofloxacin, moxifloxacin, clindamycin, erythromycin and tetracycline were higher than MSSA(P0.05). Conclusion The female reproductive tract infection with MRSA had an upward trend, and its resistance became increasingly serious. therefore,we should reinforce the surveillance of this kind of strains for the guide of rational use of antimicrobial agents in clinic.

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