[Role of CD4+CD25+Foxp3+ regulatory T cells in type 2 diabetic nephropathy].
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Le résumé fourni par la source
OBJECTIVE: To investigate the role of CD4+CD25+Foxp3+ regulatory T cells (Treg) in type 2 diabetic nephropathy and provide new clues for prevention and treatment of type 2 diabetic nephropathy. METHODS: Flow cytometry was used to analyze the expression rate of CD4+CD25+Foxp3+ Treg cells in 60 patients with type 2 diabetes and 15 normal subjects. RESULTS: No significant difference was found in the expression rate of CD4+CD25+Foxp3+ Treg cells between the control group and the type 2 diabetic patients. In the type 2 diabetic patients with microalbuminuria and macroalbuminuria, the expression of CD4+CD25+Foxp3+ Treg cells was significantly lowered in comparison with that in the control group (P<0.05), and patients with macroalbuminuria showed significantly lower expression of CD4+CD25+Foxp3+ Treg cells than the microalbuminuric patinets (P<0.05). Significant inverse correlations were noted between the disease course and the expression of CD4+CD25+Foxp3+ Treg cells and between the urinary albumin excretion rate (UAER) and the expression of CD4+CD25+Foxp3+ Treg cells. CONCLUSION: CD4+CD25+Foxp3+ Treg cells may play a role in the occurrence and development of type 2 diabetic nephropathy.
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Second Affiliated Hospital of Xi'an Jiaotong University pays non établi dans la noticeÉtablissement de santé
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Xi'an Jiaotong University College of Medicine Department of Endocrinology pays non établi dans la noticeUniversité ou école supérieure
Second Affiliated Hospital of Xi'an Jiaotong University et Department of Endocrinology — Xi'an Jiaotong University College of Medicine.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.