Expressions of PTK7 gene in human esophageal squamous cell carcinoma and their clinical significance
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Objective This study is to analyze the expression of PTK7(protein tyrosine kinase 7) protein in esophageal squamous cell carcinoma and adjacent tissue,the relationship between the expression and the development,intrusion,lymph node metastases of esophageal squamous cell carcinoma,the relationship between the expression and clinical manifestation,and diagnosis value and prognostic significance of PTK7 in esophageal squamous cell carcinoma.Methods 80 specimens of esophageal squamous cell carcinoma and 63 specimens of adjacent tissue samples were collected.PTK7 protein expression was determined by immunohistochemical streptavidin-perosidase(S-P) method.The chi-square test and Kaplan-meier were used for the analysis of PTK7 expression and other clinical related factors.Results In the cancer tissue of 80 patients with esophageal squamous cell carcinoma,PTK7 protein expression positive was found in 45 cases(χ 2 =50.17,P 0.01),PTK7 protein express negative was found in the paracancer atypical hyperplasia and normal squamous epithelium.The expression were not significantly associated with the patient's age,gender and the tumor size,Gleason score,depth of infiltration,and lymph node metastases of the esophageal squamous cell carcinoma(P 0.05).There was no obvious correlation between the expression of PTK7 protein and the 5 years of survival rate(χ 2 =0.2,P 0.1).When the comprehensive immunohistochemical score of the expression of PTK7 protein ≥5 in neoplastic tissues,5 years of survival rate decreased obviously(χ 2 =3.35,P=0.06).Conclusions There was correlation between the expression of PTK7 protein and the esophageal squamous cell carcinoma.When the comprehensive immunohistochemical score of the expression of PTK7 protein ≥5 in neoplastic tissues,5 years of survival rate decreased obviously.PTK7 protein can be used diagnosis and clinical prognosis of esophageal squamous cell carcinoma.
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