Effect of breviscapini injection(灯盏花素注射液) on the hemodynamic and heart function in chronic cor pulmonale patients
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Objective:To investigate the effect of breviscapini injection(灯盏花素注射液) on hemodynamic and heart function in chronic cor pulmonale patient. Methods:Eightyfour cases were randomly divided into two groups: treatment group(46 cases) and control group (38 cases). All patients were treated with antibiotic, relieving cough and asthma, and resolving sputum medicine. Patients with heart failure were treated with digoxin or diuresis. Besides above treatment, the treatment group was treated with breviscapini injection 50 mg once a day intravenously. Two groups were treated for 20 days and clinical efficacy, heart function, hemorrheology, bloodgas analysis were evaluated. Results:①The rate of controlled, notable efficacy, improved, fail and total effectiveness in the treatment group were respectively 17.39 percent, 45.65 percent, 30.43 percent, 6.52 percent, and 93.48 percent, while in the control group they were respectively 5.26 percent, 31.58 percent, 39.47 percent, 23.68 percent and 76.32 percent, the efficacy of the treatment group were superior to those in the control group(u=14.219 8,P0.05). ②The improvement of heart function in the treatment group was better than those in the control group (u=14.210 9, P0.05). ③In the treatment group, the blood viscosity, high shear rate viscosity, low shear rate viscosity were decreased, partical pressure of oxygen in artery and arterial oxygen saturation were increased after treatment than those in control group (all P0.01). ④In treatment group, the levels of mean pulmonary arterial pressure(mPAP), pulmonary vascular resistance(PVR), cardiac output(CO) and cardiac index(CI) were obviously improved compared to those in control group (all P0.01). Conclusion:Breviscapini injection could remarkablely change the hemorrheology, decrease pulmonary artery hypertension, improve heart function and increase clinical efficacy of chronic cor pulmonale.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.