Brain histopathology in three cases of Susac's syndrome: implications for lesion pathogenesis and treatment: Figure 1

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Abstract Context Our insight into DNA is controlled through a process called sequencing. Until recently, it was only possible to sequence DNA into short strings called “reads”. Nanopore is a new sequencing technology to produce significantly longer reads. Using nanopore sequencing, a single molecule of DNA can be sequenced without the need for time consuming PCR amplification (polymerase chain reaction is a technique used in molecular biology to amplify a single copy or a few copies of a segment of DNA across several orders of magnitude). Aims Metagenomics is the study of genetic material recovered from environmental samples. A research team from IBERS (Institute of Biological, Environmental & Rural Sciences) at Aberystwyth University have sampled metagenomes from a coal mine in South Wales using the Nanopore MinION and given initial taxonomic (classification of organisms) summaries of the contents of the microbial community. Methods Using various new software aimed for metagenomic data, we are interested to discover how well current bioinformatics software works with the data-set. We will conduct analysis and research into how well these new state of the art software works with this new long read data and try out some recent new developments for such analysis. Results Most of the software we used worked very well: we gained understanding of the ACGT count and quality of the data. However some software for bioinformatics don’t seem to work with nanopore data. Furthermore, we can conclude that low quality nanopore data may actually be quite average.

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