Response predictors in cardiac resynchronization therapy

Le résumé fourni par la source

Cardiac resynchronization therapy (CRT) has shown to improve morbidity and survival in those with reduced ejection fraction (LVEF). However, up to 30% of patients do not exhibit improvement in echo. We hypothesized that new parameters meassured by 2D strain combined with traditional ones could predict response. Methods: We included 28 consecutive patients. All studies were performed baseline and after 1 year follow-up. Images were obtained in 4,2-chamber and short axis views. For the assessment of longS and circS curves, we analyzed 14 segments. Results: Age 62.5±10.6, 86.2% men, QRS 160.9±22 ms, LVEF 27.4%±5.9, ischemic cardiomyopathy 30.8%, LBBB 82.6%. The percentage of echo responders (R) were 54% (defined as an improvement in LVEF of 5%). Baseline diferences between R and NON R are shown in the table. Table 1 Conclusions: This study identifies patient characteristics associated with response to CRT such as LBBB, smaller left atrial, interventricular asinchrony and novel parameters as greater strain values in lead placement segment, and a classical activation pattern meassured by 2D strain. Combined assessment of factors associated with reverse remodeling can be used for improved selection of patients.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.