Proceedings of Research in Clinical Practice 2010: Research in Clinical Practice was held at the Academic Centre of the John Radcliffe Hospital, Oxford, on Wednesday, 10 November 2010.

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Editors: Tom Parks, Adam Handel, Oxford University Clinical Academic Graduate School Organizing Committee: Tom Parks, Adam Handel, Tom Yates, Stephanie Worton (Academic Foundation Year 2 Doctors) and Denise Best (Academic Careers Manager), Oxford University Clinical Academic Graduate School email: oucags@medsci.ox.ac.uk Parks, T. Research in Clinical Practice, Clinical Academic Graduate School, University of Oxford When my colleagues and I first had the idea of putting on an evening poster meeting for trainees, we imagined perhaps 15 or 20 of the same familiar faces gathered in an empty-looking seminar room. ‘Research in Clinical Practice’, held at the John Radcliffe Hospital on 10 November 2010, was something quite different! The meeting, which featured two keynote presentations on careers in clinical academia and a poster session, welcomed 130 delegates from across England (one delegate travelled over 250 miles) joined by a number of Oxford's leading clinical academics. Sixty-six abstracts were selected for poster presentation on topics as diverse as barriers to Hepatitis A vaccination in ethnic minority populations within the UK and an in vitro model of mitochondrial function in liver cells. At the meeting, all of the posters were assessed by one of our panel of six senior career academic clinicians. Here, we have selected—in collaboration with Dr Michael Bannon of the Quarterly Journal of Medicine—for your interest the best 31 abstracts. It is notable that the majority of this work is that of busy, over-worked junior doctors—and most outside the remit of their day job. This level of enthusiasm was clearly reflected at the meeting; we were thrilled to overhear junior doctors telling their peers and seniors alike about their work and discussing its merits and limitations. Even those who attended just to get points for their CV became immersed! As such, although it might have been on a far larger scale than initially intended, ‘Research in Clinical Practice’ met its primary aim: to open doors to junior doctors in academic medicine. I hope you enjoy reading the synopses of the presentations on academic careers and our selection of abstracts. I am delighted that ‘Research in Clinical Practice 2011’ is already planned! Career path: Aspiring clinical academics in the UK can follow the modern, integrated pathway or the more fluid, individualized model that preceded it. The modern pathway offers job security, balanced clinical and academic training, a supportive environment and early opportunities to experience different research areas. However, there is less flexibility to work in other centres as research interests are often tied to the location of the clinical training number, and it is harder to manage the time required for research due to the formalized structure of the clinical programme. However, an Academic Clinical Fellowship provides an excellent opportunity to work in different groups, select an area of interest and then to plan and apply for a PhD and fellowship. Choosing your research: Scientific interest should affect a project choice, but in reality there are interesting questions across a wide range of disciplines. More important to a successful career is to find every likely project that is available, decide which will be enjoyable day-to-day, and which has a good supervisor for a mentor in the early phase of a career. My personal experience is of epidemiological research and meta-analysis. This work has a high level of patient interaction, clinical relevance and collaboration within the group, but is heavy on data handling, statistics and paperwork, a lot of time is spent recruiting patients and it is often viewed with less prestige. A successful project: In the early stages of a career, the most important aspect of a project is the supervisor, who should be available and on good terms with his fellows. More importantly, they should have a good record of high-impact publications, funding and mentoring fellows, as shown by previous fellows’ publications and subsequent positions. This can only be ascertained by talking to multiple supervisors and their previous fellows in person. Then it is down to luck and hard work. Combining a clinical and academic career is an attractive and rewarding option but managing this combination is challenging. Clinical training: A major challenge is to achieve appropriate clinical training while maintaining high research standards. However, matching the right research role with the right clinical job can be mutually beneficial—with the research serving to enhance quality of practice, and the clinical work stimulating research ideas and providing very practical support. Overall, clinical training will take longer but the variety and excitement along the way make it more rewarding. Integrating research: A combination of clinical work with research can give rise to many unique opportunities. One of these is working away from the UK and there are many different ways, as well as sources of funding, to do this. There is no right time in your career that you do this and it can work in different ways at different stages. There are many ways to approach this and my advice would be to be opportunistic. Most people with successful careers do not plan them! A doctorate (MD or PhD) is an important opportunity to work on a focused subject and learn many research skills. An MD offers certain flexibilities and can be more self-motivated. Providing the work is good and the publications are robust this can be equally well regarded as a PhD. Again, there are different points at which this can be fitted into your career and different times offer different advantages. Lab work can pose particular problems when experiments have long timelines. This potential hurdle can be overcome by planning experiments in advance to fit with a schedule. Work-life balance: Although it can feel difficult at times to balance all the different components of the job, let alone family and home life, mostly these jobs offer wonderful variety and a fulfilling and balanced work life. Careers can be made to be flexible and there are many excellent opportunities, so good luck. Introduction: Radiofrequency (RF) energy is being increasingly used for the thermal destruction of solid parenchymal tumours. The method has become well established in clinical practice, even though the reported results are controversial. Aims: The aim of this study was to investigate the safety and efficacy of radiofrequency ablation (RFA) application on pancreatic tissue in a porcine model. Methods: Two groups of nine animals were operated on. RF energy was applied to a predetermined area of the pancreatic head on either side of the superior mesenteric vein (SMV). 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Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.