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Accès ouvert déclaré 2013 article

Poster session Friday 13 December - PM: 13/12/2013, 14:00-18:00 * Location: Poster area

2Citations signalées — pas une note de qualité
12Institutions déclarées
8Pays d’affiliation déclarés

Résumé fourni par la source

Purpose: Cardiac deconditioning due to immobilization is a risk factor for cardiovascular disease.The physiology of cardiac adaptation to deconditioning has not been fully elucidated.The purpose of the present study was to assess the effects of 21-days of strict headdown (-6 degrees) bed-rest (BR) deconditioning on left ventricular (LV) dimensions and mass measured by MRI.Methods: Ten healthy men (mean age 32+6) were enrolled; the experiment was conducted at DLR (Koln, Germany) as part of the European Space Agency BR studies.Steady-state free precession MRI images (7mm thickness, no gap, no overlap) were obtained (Symphony 1.5T, Siemens) in a stack of short-axis views from LV base to LV apex, before (PRE), at the end of BR (HDT20), and four days after the BR conclusion (POST).Endocardial and epicardial semi-automated contouring was performed using freely available software (Segment).Results: At HDT20, significant reductions in LV mass (16%), end-diastolic (26%) and endsystolic (27%) volumes and stroke volume (27%) were observed, while ejection fraction did not change.These changes were accompanied by a measured decrease (14%) in plasma and blood volume (by gas-rebreathing technique), as well as by a significant reduction (14%) in VO2max aerobic power, measured using a graded cycle ergometer test protocol to volitional fatigue, at one day after the BR conclusion, while expiratory exchange ratio did not change.At POST, LV volumes were restored, while LV mass was still trending towards control values.Conclusions: Cardiac adaptation to deconditioning affected LV mass and dimensions, as a combined result of LV remodeling and fluids loss, accompanied by worsening in aerobic power.This should be taken into account in patients with cardiovascular diseases, when immobilized in bed, to proper adjust the therapy, or to define appropriate physical exercises when possible, in order to avoid further complications.P968

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Contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref
Poster session Friday 13 December - PM: 13/12/2013, 14:00-18:00 * Location: Poster area
Date Crossref
01/12/2013
Éditeur
Oxford University Press (OUP)
Type
journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.

Institutions déclarées

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Sujets associés

Cardiac Valve Diseases and TreatmentsCardiac Arrhythmias and TreatmentsCardiovascular Function and Risk Factors

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